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2024 Vol. 4, No. 4

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Original Article
Correlation of PM2.5 pollution and daily mortality rate of cardiovascular and cerebrovascular diseases in Northeast China through PM2.5 sources analysis
Qianqi Hong, Yang Zhao, Jing Wang, Hongyan Sun, Lanxin Deng, Jingjing Cao, Cheng Wang
2024, 4(4): 193-201. doi: 10.1515/fzm-2024-0019
[FullText HTML] (172) [PDF 1021KB](9)
Abstract:
Objective This study aims to evaluate the relationship between PM2.5 concentration and daily mortality rate from cardiovascular and cerebrovascular diseases (CCVD) in cold regions of northern China, as well as to identify the primary sources of PM2.5. Methods A time series analysis model was used to...
Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway
Nannan Tang, Jiatong Li, Zhuo Wang, Jinlu Zuo, Zifeng Zhang, Di Huang, Yannan Han, Yuqing Chen, Yilin Sun, Xiang Li, Ruxue Mu, Qingxue Ma, Jie Zhang, Jiaying Wu, He Wang, Hongxia Zhao, Xingli Dong, Zhiguo Wang, Yu Liu, Dan Zhao, Baofeng Yang
2024, 4(4): 202-211. doi: 10.1515/fzm-2024-0020
[FullText HTML] (204) [PDF 2307KB](15)
Abstract:
Background Small ubiquitin-like modifiers (SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer, diabetes, heart failure, and neurological diseases. However, whether SUMO inhibitors also have anti-hypertension effect remains yet t...
GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy
Donghua Liu, Yang Zhang, Xin Liu, Qihe Huang, Xiaofang Zhang, Rui Yang, Yue Zhao, Penghui Li, Jiayi He, Kexiao Zhang, Zhenwei Pan, Huiwen Liu, Baofeng Yang
2024, 4(4): 212-223. doi: 10.1515/fzm-2024-0021
[FullText HTML] (93) [PDF 6479KB](5)
Abstract:
Objective Our study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on the function of endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow and to explore the mechanistic relationship between GDF11 and age-related ALP impairment...
ISG15 promotes M5-induced hacat cell proliferation through Wnt signaling in psoriasis
Xianqi Sun, Yuzhen Li, Huiwen Yu, Jiaying Lin, Chen Wang, Quanlin Liu, Bingxue Bai
2024, 4(4): 224-232. doi: 10.1515/fzm-2024-0022
[FullText HTML] (75) [PDF 4808KB](3)
Abstract:
Objective Psoriasis is a common chronic, recurrent, immune-mediated inflammatory skin disease, which tends to occur in cold areas. Its pathogenesis is currently unclear. This study aims to screen differentially expressed genes in the psoriasis dataset, identify the central genes, detect the expressi...
Identification of hub genes and pathways in mouse with cold exposure
Xu Wang, Hongbo Hu, Ying Zhang
2024, 4(4): 233-241. doi: 10.1515/fzm-2024-0023
[FullText HTML] (144) [PDF 6892KB](8)
Abstract:
Background Cold exposure is linked to numerous diseases, yet the changes in key genes and pathways in mice under cold exposure remain unexplored. Understanding these alterations could offer insights into the mechanisms of cold resistance and contribute valuable ideas for treating cold-related diseas...
The function and effect on prognosis of ANXA2 in gastric cancer peritoneal metastasis patients in cold region
Shiyang Jin, Longxu Liang, Xiaoyi Huang, Kuan Wang
2024, 4(4): 242-251. doi: 10.1515/fzm-2024-0024
[FullText HTML] (84) [PDF 5379KB](3)
Abstract:
Objective Heilongjiang Province is part of the northern cold areas of China, where gastric cancer is one of the most common gastrointestinal malignancies. Peritoneal metastases (PM) are the leading cause of mortality among patients. This study conducted bioinformatics and basic research on the gene ...
Arthroscopic patellar denervation with microfracture for treating patellofemoral arthritis in cold weather conditions: a retrospective clinical analysis
Xinnan Ma, Xin Zhang, Yingkai Ma, Yonghou Zhao, Kai Liu
2024, 4(4): 252-256. doi: 10.1515/fzm-2024-0025
[FullText HTML] (58) [PDF 344KB](4)
Abstract:
Objective To evaluate the clinical efficacy of combining arthroscopic patellar denervation with microfracture in the treatment of patellofemoral arthritis under cold weather conditions. Methods A total of 134 patients with patellofemoral arthritis who underwent treatment between June 2019 and June 2...

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