Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway

doi: 10.1515/fzm-2024-0020

• Nannan Tang^{1, #} , 
• Jiatong Li^{1, 2, 3, #} , 
• Zhuo Wang^{1, #} , 
• Jinlu Zuo¹ , 
• Zifeng Zhang¹ , 
• Di Huang⁵ , 
• Yannan Han¹ , 
• Yuqing Chen¹ , 
• Yilin Sun¹ , 
• Xiang Li¹ , 
• Ruxue Mu¹ , 
• Qingxue Ma¹ , 
• Jie Zhang¹ , 
• Jiaying Wu¹ , 
• He Wang¹ , 
• Hongxia Zhao^{1, 4} , 
• Xingli Dong¹ , 
• Zhiguo Wang¹ , 
• Yu Liu^{1 ,  ,}  , 
• Dan Zhao^{5 ,  ,}  , 
• Baofeng Yang^{1, 4 ,  ,} 

• 1.

  State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China

• 2.

  State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China

• 3.

  Biliary and Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

• 4.

  Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China

• 5.

  Department of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China