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• 1 Moderate cold exposure contributes to the extension of lifespan by alleviating the aggregation of disease-related proteins
• 2 Advances in the research field of osteoporosis in cold areas
• 3 Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway
• 4 The link between dietary nutrients intake and cardiovascular diseases in cold regions