Volume 3 Issue 2
Apr.  2023
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Huanyu Lu, Wenjing Luo. Multiple inducible thermogenic mechanisms in the development of cold acclimatization[J]. Frigid Zone Medicine, 2023, 3(2): 83-91. doi: 10.2478/fzm-2023-0011
Citation: Huanyu Lu, Wenjing Luo. Multiple inducible thermogenic mechanisms in the development of cold acclimatization[J]. Frigid Zone Medicine, 2023, 3(2): 83-91. doi: 10.2478/fzm-2023-0011

Multiple inducible thermogenic mechanisms in the development of cold acclimatization

doi: 10.2478/fzm-2023-0011
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  • Corresponding author: Wenjing Luo, E-mail: luowenj@fmmu.edu.cn
  • Received Date: 2022-06-26
  • Accepted Date: 2022-12-20
  • Available Online: 2023-04-25
  • Extreme cold environment can threaten human health and life through increasing the risk of myocardial infarction, stroke, frostbite, and hypothermia. Insufficient heat production to maintain core body temperature is a major cause of cold injury. To cope with cold stress, human and other mammals have developed the capacity of cold acclimatization to adapt to such a harsh environment. Adaptive non-shivering thermogenesis is a ubiquitous form of cold acclimatization. This review article systematically summarizes the role of three inducible thermogenic forms, including food intake, circadian rhythms, and cold exposure in mediating non-shivering thermogenesis under cold exposure and presents the potential interventions for minimizing the adverse health consequences of cold temperature.

     

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