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Volume 3 Issue 1
Jan.  2023
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Article Navigation >  Frigid Zone Medicine  > 2023  >  3(1): 37-41
Fefelova Elena Viktorovna, Karavaeva Tatyana Mikhailovna, Parshina Anastasia Anatolyevna, Ma Van De Vasilina Denisovna, Tereshkov Pavel Petrovich. Aminothiols exchange in coronavirus disease 2019[J]. Frigid Zone Medicine, 2023, 3(1): 37-41. doi: 10.2478/fzm-2023-0006
Citation: Fefelova Elena Viktorovna, Karavaeva Tatyana Mikhailovna, Parshina Anastasia Anatolyevna, Ma Van De Vasilina Denisovna, Tereshkov Pavel Petrovich. Aminothiols exchange in coronavirus disease 2019[J]. Frigid Zone Medicine, 2023, 3(1): 37-41. doi: 10.2478/fzm-2023-0006
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Aminothiols exchange in coronavirus disease 2019

doi: 10.2478/fzm-2023-0006
  • 1.

    Department of Pathological Physiology, Chita State Medical Academy, Chita 672090, Russia

  • 2.

    Department of Chemistry and Biochemistry, Chita State Medical Academy, Chita 672090, Russia

  • 3.

    Department of Faculty Therapy, Chita State Medical Academy, Chita 672090, Russia

  • 4.

    Laboratory of Experimental and Clinical Biochemistry and Immunology, Chita State Medical Academy, Chita 672090, Russia

More Information
  • Corresponding author: Fefelova Elena Viktorovna, E-mail: fefelova.elena@mail.ru
  • Received Date: 2022-05-31
  • Accepted Date: 2022-10-24
    • Available Online: 2023-01-01
    Abstract
  •   Objective  Clinical manifestation of the inflammatory process in its relation to biochemical markers (total cysteine [Cys], cysteine-glycine [CysGly], glutathione [GSH], glutamate-cysteine [Glu-Cys], homocysteine [Hcy], the ratio of reduced to oxidized glutathione [GSH/GSSG], the ratio of reduced to oxidized cysteine [CySH/CySS], malondialdehyde-oxidized low-density lipoproteins [MDA-oxLDL]) has been studied in patients with coronavirus disease 2019 (COVID-19).  Material and methods  48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our research. The participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6 (IL-6).  Results  All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6 (by 54.6%). There was no comorbidity in patients with mild COVID-19 (nasopharyngitis symptoms) and in healthy control subjects. 50% of patients with lung damage had accompanying diseases. Alterations of aminoethyl metabolism were detected in COVID-19 patients: as reflected by the decreased levels of Cys, CysGly, and Glu-Cys and the increased levels of GSH as compared to the control group.  Conclusion  Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation, specifically MDA-oxLDL.

     

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