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Volume 2 Issue 4
Oct.  2022
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Article Navigation >  Frigid Zone Medicine  > 2022  >  2(4): 225-243
Yongting Zhao, Xiaofang Zhang, Haihai Liang, Lihong Wang. Antidiabetic agents: Do they hit the right targets?[J]. Frigid Zone Medicine, 2022, 2(4): 225-243. doi: 10.2478/fzm-2022-0030
Citation: Yongting Zhao, Xiaofang Zhang, Haihai Liang, Lihong Wang. Antidiabetic agents: Do they hit the right targets?[J]. Frigid Zone Medicine, 2022, 2(4): 225-243. doi: 10.2478/fzm-2022-0030
shu

Antidiabetic agents: Do they hit the right targets?

doi: 10.2478/fzm-2022-0030
  • 1.

    Department of Endocrinology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

  • 2.

    Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

  • 3.

    Department of Pharmacology (State-Province Key Laboratories of BiomedicinePharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China

More Information
  • Corresponding author: Lihong Wang, E-mail: nd6688@163.com
  • Received Date: 2021-07-09
  • Accepted Date: 2022-04-21
    • Available Online: 2022-10-30
    Abstract
  • Diabetes mellitus (DM) is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance (IR). Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels, heart, kidney, retina, nervous system, etc. In recent years, DM has attracted more and more attention due to its high morbidity and mortality. In addition to achieve effective glycemic control, prevention of complications has also been considered a priority for type 2 diabetes mellitus (T2DM) management. Herein, we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs.

     

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