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Volume 2 Issue 1
Mar.  2022
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Article Navigation >  Frigid Zone Medicine  > 2022  >  2(1): 10-24
Haijian Sun, Xiaowei Nie, Kangying Yu, Jinsong Bian. Therapeutic potential of gasotransmitters for cold stress-related cardiovascular disease[J]. Frigid Zone Medicine, 2022, 2(1): 10-24. doi: 10.2478/fzm-2022-0002
Citation: Haijian Sun, Xiaowei Nie, Kangying Yu, Jinsong Bian. Therapeutic potential of gasotransmitters for cold stress-related cardiovascular disease[J]. Frigid Zone Medicine, 2022, 2(1): 10-24. doi: 10.2478/fzm-2022-0002
shu

Therapeutic potential of gasotransmitters for cold stress-related cardiovascular disease

doi: 10.2478/fzm-2022-0002
  • 1.

    School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

  • 2.

    Shenzhen Key Laboratory of Respiratory Diseases, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518055, China

  • 3.

    Nursing School of Wuxi Taihu University, Wuxi 214064, China

  • 4.

    Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China

  • 5.

    National University of Singapore (Suzhou) Research Institute, Suzhou 215000, China

More Information
  • Corresponding author: Jinsong Bian, E-mail: bianjs@sustech.edu.cn
  • Received Date: 2021-10-08
  • Accepted Date: 2021-12-02
    • Available Online: 2022-03-01
    Abstract
  • Growing evidence has shown that exposure to low ambient temperature poses a huge challenge to human health globally. Actually, cold stress is closely associated with a higher incidence of cardiovascular morbidity and mortality in winter or in cold regions. Cellular and molecular mechanisms underlying cardiovascular complications in response to cold exposure have yet to be fully clarified. Considering that cold exposure is an important risk of cardiovascular complications, it is necessary to clarify the molecular mechanism of cold stress-induced cardiovascular diseases and to develop effective intervention strategies. Hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO) are wellknown gasotransmitters that are endogenously produced in many biological systems. Accumulating studies have demonstrated that these gasotransmitters play a critical role in a wide spectrum of physiological and/or pathophysiological processes by regulating numerous signaling pathways. These gas signal molecules are emerging as important players in cardiovascular homeostasis, and disruption of these gasotransmitters is critically implicated in cardiovascular anomalies, such as hypertension, atherosclerosis, myocardial ischemia, heart failure, and stroke. Also, evidence is emerging that H2S, NO, and CO may be involved in the pathologies of cold stress-induced cardiovascular ailments. In this review, we aim to highlight and discuss the recent advances towards the development of gasotransmitters-based therapeutics for cold stressrelated cardiovascular pathogenesis. We believe that the effects of H2S, NO, and CO on cardiovascular regulation under cold environment will attract tremendous interest in the near future as they serve as novel regulators of cardiovascular biology in cold environment.

     

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