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Volume 5 Issue 1
Jan.  2025
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Article Navigation >  Frigid Zone Medicine  > 2025  >  5(1): 50-57
Jiayu Zhu, Jiaqi Zhang, Qi Yu, Liyan Liu, Rennan Feng. Association of dietary phytosterols with prevalence of metabolic dysfunction-associated fatty liver disease in adult population of Northeastern China: An internet-based cross-sectional study[J]. Frigid Zone Medicine, 2025, 5(1): 50-57. doi: 10.1515/fzm-2025-0005
Citation: Jiayu Zhu, Jiaqi Zhang, Qi Yu, Liyan Liu, Rennan Feng. Association of dietary phytosterols with prevalence of metabolic dysfunction-associated fatty liver disease in adult population of Northeastern China: An internet-based cross-sectional study[J]. Frigid Zone Medicine, 2025, 5(1): 50-57. doi: 10.1515/fzm-2025-0005
shu

Association of dietary phytosterols with prevalence of metabolic dysfunction-associated fatty liver disease in adult population of Northeastern China: An internet-based cross-sectional study

doi: 10.1515/fzm-2025-0005
  • 1.

    Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150081, China

  • 2.

    Key Laboratory of Precision Nutrition and Health of Ministry of Education, School of Public Health, Harbin Medical University, Harbin 150081, China

Funds:

Heilongjiang Provincial Postdoctoral Commission Science Foundation LH2024H021

National Financial Projects-Assessment and Application of Nutrients Requirement and Food Environment for Chinese Residents 131031107000210003

Opening Project of Key Laboratory of Trace Element and Nutrition, National Health Commission of the People's Republic of China WLKFZ202402

the National Natural Science Foundation of China 82273612

the Open Project of Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology MCD-2023-1-09

More Information
    Abstract
  •   Objective  The benefits of phytosterols have attracted growing interest, but their association with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) has rarely been reported in population-based studies. This research aimed to investigate the correlation between dietary phytosterols and MAFLD.  Methods  Phytosterols intake was evaluated using an internet-based dietary questionnaire targeted at the Chinese population. Conditional logistic regression models were employed to investigate dose-response relationships between phytosterol intake and MAFLD, as well as the potential preventive role of phytosterols. Restricted Cubic Spline (RCS) analyses were conducted to examine associations between phytosterols intake and MAFLD. Additionally, a quantile-based g-computation (qgcomp) method was applied to explore the combined effect of campesterol, stigmasterol, β-sitostelane, campestane, and β-sitosterol on MAFLD.  Results  Significant inverse relationships were found between total phytosterols and MAFLD (OR, 0.19; 95% CI, 0.11-0.32; P < 0.001), campesterol (OR, 0.22; 95% CI, 0.13-0.37; P < 0.001), stigmasterol (OR, 0.17; 95% CI, 0.10-0.30; P < 0.001), β-sitostelane (OR, 0.26; 95% CI, 0.16-0.45; P < 0.001), campestane (OR, 0.23; 95% CI, 0.14-0.39; P < 0.001), and β-sitosterol (OR, 0.17; 95% CI, 0.10-0.29; P < 0.001). The qgcomp analysis showed a significant negative association between the five phytosterols and MAFLD (OR, 0.58; 95% CI, 0.50-0.67; P < 0.001). Additionally, the qgcomp analysis revealed that the combination of these five phytosterols was inversely associated with MAFLD, with stigmasterol contributing the most (weight = 0.70).  Conclusion  Higher intake of phytosterols was associated with a reduced prevalence of MAFLD, with stigmasterol showing the most significant inverse relationship. Further research is needed to clarify the relationship between phytosterols and MAFLD.

     

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