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Volume 5 Issue 1
Jan.  2025
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Article Navigation >  Frigid Zone Medicine  > 2025  >  5(1): 22-41
Zhiwei Zhang, Yongjin Long, Ming Li, Chunpeng Lyu, Xianglan Chen, Qiaoyu Wang, Kunying Yang, Jiahui Li, Wei Zhang, Dianjun Sun. SPSB4 as a risk factor for papillary thyroid cancer: Enhancing cell vitality under excess iodine exposure[J]. Frigid Zone Medicine, 2025, 5(1): 22-41. doi: 10.1515/fzm-2025-0003
Citation: Zhiwei Zhang, Yongjin Long, Ming Li, Chunpeng Lyu, Xianglan Chen, Qiaoyu Wang, Kunying Yang, Jiahui Li, Wei Zhang, Dianjun Sun. SPSB4 as a risk factor for papillary thyroid cancer: Enhancing cell vitality under excess iodine exposure[J]. Frigid Zone Medicine, 2025, 5(1): 22-41. doi: 10.1515/fzm-2025-0003
shu

SPSB4 as a risk factor for papillary thyroid cancer: Enhancing cell vitality under excess iodine exposure

doi: 10.1515/fzm-2025-0003
  • 1.

    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China

  • 2.

    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China

  • 3.

    Key Lab of Etiology and Epidemiology, Ministry of Health Education Bureau of Heilongjiang Province & Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin 150081, China

Funds:  Study on the relationship and mechanism between different water iodine exposure and the incidence of different thyroid diseases diseases supported by National Natural Science Foundation of China (8183000355) were recognized by Zhang Z W, Long Y J, Li M, Lyu C P, Chen X L, Wang Q Y, Yang K Y, Li J H, Zhang W and Sun D J
More Information
  • Corresponding author: Wei Zhang, E-mail: zwhxd@126.com; Dianjun Sun, E-mail: hrbmusdj@163.com
  • Received Date: 2024-04-26
  • Accepted Date: 2024-08-28
    • Available Online: 2025-01-05
    Abstract
  •   Objective  The varying environmental exposure to iodine has long been a topic of interest, particularly given the noticeable increase in the incidence of papillary thyroid carcinoma (PTC) compared to other histopathological subtypes globally. This rise in thyroid cancer incidence has been attributed to several factors, including improved detection of early tumors, a higher prevalence of modifiable individual risk factors, and differing exposure to environmental risk factors such as iodine levels. This study aims to explore the epigenetic mechanisms that promote thyroid cancer progression under excess iodine exposure.  Materials and methods  This study outlines the following strategy: (i) risk factors were identified through statistical analysis of questionnaire responses in a retrospective iatrogenic study; (ii) following the identification of risk factors, RNA sequencing was performed using tissues from iodine-adequate (IA) and iodine-excess (IE) regions; (iii) candidate hub genes were selected via bioinformatics analysis; (iv) molecular biological techniques were employed to verify the functionality of the key gene.  Results  Through careful selection, we focused on SPSB4, a ubiquitin ligase previously unreported in relation to both iodine and thyroid cancer. By optimizing the dosage of PTC cell line activities, we determined how varying iodine levels can either enhance or impair the vitality of thyroid cancer cells. As anticipated, migration and invasion assays revealed significant changes when SPSB4 function was disrupted at the critical dose of KIO3.  Conclusions  In terms of epigenetic alterations, SPSB4 emerges as a promising candidate for further investigation, particularly in understanding thyroid cancer progression and potential carcinogenesis. Moreover, E3 ubiquitin ligases, including SPSB4, play a role in orchestrating adipose thermogenesis to maintain body temperature during cold stimuli. This study could also shed light on the influence of iodine on thermogenesis mediated by SPSB4 under cold conditions, while suggesting future exploration of SPSB4's effects on thyroid cancer in colder regions.

     

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