Submission systemSubmit
Advanced Search
Volume 4 Issue 2
Apr.  2024
Turn off MathJax
Article Contents
Article Navigation >  Frigid Zone Medicine  > 2024  >  4(2): 96-101
Siyu Hao, Yu Zhang, Anqi Yin, Ying Lyu, Nannan Tong, Jiangtian Tian, Yuzhen Li. Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population[J]. Frigid Zone Medicine, 2024, 4(2): 96-101. doi: 10.1515/fzm-2024-0010
Citation: Siyu Hao, Yu Zhang, Anqi Yin, Ying Lyu, Nannan Tong, Jiangtian Tian, Yuzhen Li. Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population[J]. Frigid Zone Medicine, 2024, 4(2): 96-101. doi: 10.1515/fzm-2024-0010
shu

Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population

doi: 10.1515/fzm-2024-0010
  • 1.

    Department of Dermatology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China

  • 2.

    The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150000, China

  • 3.

    Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China

Funds:

grants from the National Natural Science Foundation of China 82304000

More Information
    Abstract
  •   Background  Psoriasis is a disease caused by genetics and immune system dysfunction, affecting the skin and joints. Toll-like receptors (TLRs) play an important role in triggering the innate immune response and controlling adaptive immunity. The role of TLR2 in the progression of psoriasis is not well understood.  Methods  A case-control study was conducted on a northern Chinese Han population, consisting of psoriasis patients and healthy control subjects. Genotyping was performed using the tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), and allele and genotype frequencies of four SNPs in TLR2 were analyzed in 270 psoriasis patients and 246 healthy controls.  Results  Four TLR2 SNPs (rs11938228, rs4696480, rs3804099, rs5743699) were genotyped and found to be in linkage disequilibrium. The genotype distributions of rs11938228 and rs4696480 in two groups were in Hardy-Weinberg equilibrium and statistically significant except for the overdominance model. The haplotypes ATTC and ATCC were found to be protective against psoriasis.  Conclusion  Our study found a correlation between TLR2 genetic variations and the likelihood of psoriasis in northern China.

     

    • FullText(HTML)
  • loading
    • References(26)
  • [1]
    Griffiths C E, Barker J N. Pathogenesis and clinical features of Psoriasis. Lancet, 2007; 370(9583): 263-271. doi: 10.1016/S0140-6736(07)61128-3
    [2]
    Yin X, Low H Q, Wang L, et al. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun, 2015; 6(1): 6916. doi: 10.1038/ncomms7916
    [3]
    Grän F, Kerstan A, Serfling E, et al. Current developments in the immunology of psoriasis. Yale J Biol Med, 2020; 93(1): 97-110.
    [4]
    Conrad C, Gilliet M. Psoriasis: from pathogenesis to targeted therapies. Clin Rev Allergy Immunol, 2018; 54(1): 102-113. doi: 10.1007/s12016-018-8668-1
    [5]
    Miller L S. Toll-like receptors in skin. Adv Dermatol, 2008, 24: 71-87. doi: 10.1016/j.yadr.2008.09.004
    [6]
    Chen J-Q, Szodoray P, Zeher M. Toll-Like receptor pathways in autoimmune diseases. Yale J Biol Med, 2016; 50(1): 1-17. doi: 10.1007/s12016-015-8473-z
    [7]
    Ermertcan A T, Öztürk F, Gündüz K. Toll-like receptors and skin: TLRs and skin. Journal of the J Eur Acad Dermatol Venereol, 2011; 25(9): 997-1006. doi: 10.1111/j.1468-3083.2011.04049.x
    [8]
    Marks K E, Cho K, Stickling C, et al. Toll-like receptor 2 in autoimmune inflammation. Immune Network, 2021; 21(3): e18. doi: 10.4110/in.2021.21.e18
    [9]
    Garcia-Rodriguez S, Arias-Santiago S, Perandrés-López R, et al. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis: TLR4 up-regulation in psoriasis PBMC. J Eur Acad Dermatol Venereol, 2013; 27(2): 242-250. doi: 10.1111/j.1468-3083.2011.04372.x
    [10]
    Carrasco S, Neves F S, Fonseca M H, et al. Toll-like Receptor (TLR) 2 is upregulated on peripheral blood monocytes of patients with psoriatic arthritis: a role for a gram-positive inflammatory trigger? Clin Exp Rheumatol, 2011; 29(6): 958-962.
    [11]
    Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2. A Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Gene, 2010; 42(11): 985-990. doi: 10.1038/ng.694
    [12]
    Stuart P E, Nair R P, Ellinghaus E, et al. Genome-wide association analysis identifies three psoriasis susceptibility Loci. Nat Gene, 2010, 42(11): 1000-1004. doi: 10.1038/ng.693
    [13]
    Sun L D, Cheng H, Wang Z X, et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nate Gene, 2010; 42(11): 1005-1009. doi: 10.1038/ng.690
    [14]
    Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate Immunity. Nat Gene, 2012; 44(12): 1341-1348. doi: 10.1038/ng.2467
    [15]
    Shi G, Wang T, Li S, et al. TLR2 and TLR4 polymorphisms in Southern Chinese psoriasis vulgaris patients. J Dermatol Sci, 2016; 83(2): 145-147. doi: 10.1016/j.jdermsci.2016.04.014
    [16]
    Sabah-Özcan S, Gürel G. The polymorphism rs4696480 in the TLR2 gene is associated with psoriasis patients in the Turkish Population. Immunol Let, 2019; 211: 28-32. doi: 10.1016/j.imlet.2019.05.008
    [17]
    Gowin E, Świątek-Kościelna B, Kałużna E, et al. Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family Members. Int J Infect Dis, 2017; 60: 23-28. doi: 10.1016/j.ijid.2017.04.024
    [18]
    Zhou B, Liang S, Shang S, et al. Association of TLR2 and TLR9 gene polymorphisms with atopic dermatitis: a systematic review and meta-analysis with trial sequential Analysis. Immunol Med, 2023; 46(1): 32-44. doi: 10.1080/25785826.2022.2132683
    [19]
    Loft N D, Skov L, Iversen L, et al. Associations between functional polymorphisms and response to biological treatment in Danish patients with Psoriasis. Pharmacogenomics J, 2018; 18(3): 494-500. doi: 10.1038/tpj.2017.31
    [20]
    Lorenz E, Mira J P, Cornish K L, et al. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun, 2000; 68(11): 6398-6401. doi: 10.1128/IAI.68.11.6398-6401.2000
    [21]
    Zhou B, Liang S, Shang S, et al. Association of TLR2 and TLR9 gene polymorphisms with atopic dermatitis: a systematic review and meta-analysis with trial sequential Analysis. Immunol Med, 2022: 1-13.
    [22]
    Potaczek D P, Przytulska-Szczerbik A, Bazan-Socha S, et al. Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic Dermatitis. Human Immunol, 2020; 81(12): 709-713. doi: 10.1016/j.humimm.2020.08.002
    [23]
    Elloumi N, Tahri S, Fakhfakh R, et al. Role of innate immune receptors TLR4 and TLR2 polymorphisms in systemic lupus erythematosus Susceptibility. Ann Human Gene, 2022; 86(3): 137-144. doi: 10.1111/ahg.12458
    [24]
    Zhang Y, Wang H C, Feng C, et al. Analysis of the association of polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with atopic dermatitis risk. Immunol Invest, 2019; 48(2): 169-180. doi: 10.1080/08820139.2018.1508228
    [25]
    Zhang F, Gao X D, Wu W W, et al. Polymorphisms in Toll-like receptors 2, 4 and 5 are associated with legionella pneumophila Infection. Infection, 2013; 41(5): 941-948. doi: 10.1007/s15010-013-0444-9
    [26]
    Shi G, Wang T, Li S, et al. TLR2 and TLR4 polymorphisms in Southern Chinese psoriasis vulgaris patients. J Dermatol Sci, 2016; 83(2): 145-147. doi: 10.1016/j.jdermsci.2016.04.014
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(7)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (132) PDF downloads(9) Cited by()
    Proportional views
    Related

    Contact Us

    Editorial Office: Frigid Zone Medicine, Editorial Office of Frigid Zone Medicine, Heilongjiang Health Development Research Center, Zhongshan Road 112, Xiangfang District, Harbin, 150036, China

    Tel: 0451-87253028

    E-mail: editorialoffice@frigidzonemedicine.com

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    Links

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return