2021 Vol. 1, No. 2

Display Method:
Review
Mammalian hibernation: a unique model for medical research
Xin Xing, Shiqiang Wang
2021, 1(2): 65-68. doi: 10.2478/fzm-2021-0008
Abstract:

Hibernation is an adaptive behavior for some small animals to survive cold winter. Hibernating mammals usually down-regulate their body temperature from ~37℃ to only a few degrees. During the evolution, mammalian hibernators have inherited unique strategies to survive extreme conditions that may lea...

Role of microRNAs in the process of metformin treating multiple diseases
Ningning Ma, Jing Chen, Jin Ren
2021, 1(2): 69-78. doi: 10.2478/fzm-2021-0009
Abstract:

Metformin as the first-line treatment for type 2 diabetes mellitus has been discovered to exert beneficial effects on many diseases for nearly ten years, but its specific mechanism is still unclear. As a new class of gene expression regulators with pleiotropic properties, microRNAs (miRNAs) particip...

Chinese herbal medicines with beneficial effects
De-an Guo, Wenlong Wei, Changliang Yao, Jianqing Zhang, Qirui Bi
2021, 1(2): 79-83. doi: 10.2478/fzm-2021-0010
Abstract:

Among the vast resources of traditional Chinese medicine (TCM) herbal species, only a handful of Chinese herbs are growing in frigid regions or extreme environment but they have a unique property. The most recognizable TCM herb falling in this category is Panax ginseng, which is widely considered th...

Original Article
Overexpression of microRNA-135b-5p attenuates acute myocardial infarction injury through its antioxidant and anti-apptotic properties
Yanyan Liu, Yahan Yu, Xinyao Wang, Guanqun Liu, Xinda Yin, Yunlong Bai, Zhimin Du
2021, 1(2): 85-94. doi: 10.2478/fzm-2021-0011
Abstract:

Objective: Myocardial infarction (MI) remains the leading cause of morbidity and mortality due partly to the limited regenerative capacity of cardiomyocytes to replace cardiomyocyte lost due to apoptosis. Inhibiting cardiomyocyte apoptosis is recognized as an effective therapeutic approach for MI. M...

Tranilast treats cold-related hypertension by reducing the expression of NLRP3 inflammasome
Hui Yu, Yun Zhou, Yu Duan, Yunlong Gao, Ning Fang, Jiawei Zhang, Yue Li
2021, 1(2): 95-101. doi: 10.2478/fzm-2021-0012
Abstract:

Objective: Cold exposure is associated with increased prevalence of hypertension and the related severe cardiovascular events. Aberrant activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the development of hypertension....

Ibuprofen treatment for patent ductus arteriosus in preterm infants: a retrospective cohort study in a leading Chinese center
Jia Chen, Jinghua Luo, Hao Liu, Xue Du, Shan Zhang, Zizhen Wang, Liu He, Zhichun Feng
2021, 1(2): 103-110. doi: 10.2478/fzm-2021-0013
Abstract:

Objective There is a dilemma of ibuprofen treatment with patent ductus arteriosus (PDA) as to how and when to treat. We aimed to clarify this issue in very preterm infants (VPIs; < 32 weeks). Methods: This retrospective study included 1 659 VPIs who were diagnosed with PDA according to echocardio...

Changes of calcitonin gene-related peptide and other serological indicators in vestibular migraine patients
Xinyi Liu, Yonghui Pan, Jingjing Wang, Lei Zhang, Junli Zhang
2021, 1(2): 111-118. doi: 10.2478/fzm-2021-0014
Abstract:
Objective It aims to evaluate the diagnostic ability of CGRP and other blood indicators in vestibular migraine (VM) patients, and to explain the potential pathological effects of these biomarkers. The hypothesis of VM being a variant of migraine was examined. Methods A total of 32 VM patients, 35 mi...
Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy
Yan Feng, Ying Li, Xinling Yang, Limin Han, Luning Wang, Shan Gao, Ruixue Yin, Xue Wang, Jiayang Li, Meiming Liu, Baiyan Li
2021, 1(2): 119-126. doi: 10.2478/fzm-2021-0015
Abstract:
Objective Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling ...
Communication
Utilizing local anti-cancer treatment and online medical service during the COVID-19 pandemic
Qi Wang, Zhouqiao Wu, Jinyao Shi, Kan Xue, Ziyu Li, Jiafu Ji
2021, 1(2): 127-128. doi: 10.2478/fzm-2021-0016
Abstract: