2021 Vol. 1, No. 1

Display Method:
Editorial
Inaugural Editorial
Baofeng Yang
2021, 1(1): 1-1. doi: 10.2478/fzm-2021-0001
Abstract:
Review
Prevention and control measures of the major cold-region diseases (hypertension) in China
Zhenwei Pan, Yong Zhang, Tengfei Pan, Haihai Liang, Baofeng Yang
2021, 1(1): 3-8. doi: 10.2478/fzm-2021-0002
Abstract:
Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events. There are more than 270 million hypertension patients in China, and the prevalence of hypertension in the high-latitude cold areas is significantly higher than ...
Hydrogen sulfide, microbiota, and sulfur amino acid restriction diet
Rui Wang
2021, 1(1): 9-16. doi: 10.2478/fzm-2021-0003
Abstract:
Eukaryotes and microbiota produce H2S, using the same substrates and enzymes which constitute the reverse-trans-sulfuration and transsulfuration pathways. The homeostasis of gut microbiota impacts on the structural and functional integrity of gut epithelial barrier. Microbiota also serve as signalli...
Discussion on the model of community management of chronic diseases in cold areas
Rui Jiang, Yuquan Zhao, Yongchen Wang
2021, 1(1): 17-22. doi: 10.2478/fzm-2021-0004
Abstract:
Because of the overbearing low temperature, cold areas increase the morbidity and mortality of chronic non-communicable diseases (chronic diseases) in exposed populations. With the growth of the aging population and the superposition of lifestyle risk factors, the number of people with chronic disea...
Traditional Chinese medicine in the treatment of high incidence diseases in cold areas: the thrombotic diseases
Xueqing Tang, Xin Liu, Monayo Seth Mikaye, Hongrui Zhao, Yong Zhang
2021, 1(1): 23-44. doi: 10.2478/fzm-2021-0005
Abstract:
Thrombotic diseases are the leading causes of death worldwide, especially in cold climates. Traditional Chinese medicine (TCM)-based therapies have gained increasing popularity worldwide, but also raised some concerns about its efficacy, safety profile and exact mechanisms. TCM has been traditionall...
Original Article
Tridepsides from the endophytic fungus colletotrichum gloeosporioides associated with a toxic medicinal plant tylophora ovata
Sen-Feng Sun, Shao Zhu, Hai-Yan Cao, Yun-Bao Liu, Shi-Shan Yu
2021, 1(1): 45-51. doi: 10.2478/fzm-2021-0006
Abstract:
Introduction Bioactive secondary metabolites from the microbes living in frigid, toxic or other extreme environments are emerging as a new medicinal resource. Here, we report the discovery of new antidiabetic and anti-inflammatory compounds with novel structures from endophytic fungi hosted toxic me...
Ablation of apoptosis-stimulating of p53 protein 1 protects mice from acute hepatic injury and dysfunction via NF-кB pathway in CCl4-induced hepatotoxicity
Daba Tolessa Muleta, Xiang Huang, Timur Yagudin, Ying Yang, Jiangang Wang, Xiaoyu Fu, Yue Zhao, Haiyu Gao, Yang Zhou, Zhenwei Pan, Xiangyu Zhong
2021, 1(1): 53-64. doi: 10.2478/fzm-2021-0007
Abstract:
Acute liver injury (ALI) is characterized by apoptosis, inflammation, and oxidative stress, and pathogenic mechanism of ALI is poorly understood. Apoptosis-stimulating of p53 protein 1 (ASPP1) is involved in environmental responses, tumor growth, and NF-KB activity, which is of critical importance t...