Frigid Zone Medicine

Article search, find a total of 1 relevant information:

Sort By:: Relevance; Published

Display per page：: 10; 20; 30; 50

Display per page：

Select articles

Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

Jiaxin Guan, Lu Gan, Chaoqi Yan, Boyu Hou, Ying Fan

2024, 4(2): 102-109. doi: 10.1515/fzm-2024-0011

Keywords: cerebral small vascular disease, degenerative disease, leukoaraiosis, white matter hyperintensities, lacunar infarction, 25-hydroxyvitamin D, ICAM-1, fibrinogen-C, inflammatory factor, fazekas scale

[FullText HTML] (76) [PDF 821KB](7)

Background and objective Commonly plaguing in the frigid zone of the world, vitamin D deficiency, as indicated by low levels of 25-hydroxyvitamin D, exacerbated inflammatory responses and impaired endothelial function. Leukoaraiosis (LA) is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory responses. This study aimed to investigate the impact of vitamin D on the severity of LA. Methods Patients with LA were categorized based on 3.0 T brain MRI findings into mild (N = 43), moderate (N = 40), or severe groups (N = 29) using the Fazekas scale (scoring 1-6). A control group consisting of 41 healthy individuals was included. Serum fibrinogen C, homocysteine, plasma 25-hydroxyvitamin D, and intercellular cell adhesion molecule-1 (ICAM-1) levels were measured using ELISA. Results All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group, with a more pronounced decrease observed as LA severity increased. Low plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA (P < 0.05) according to Multiple logistic regression analysis. Additionally, a negative association was observed between 25-hydroxyvitamin D and vascular inflammatory factor ICAM-1. Conclusions Disease severity positively correlated with levels of the inflammatory marker ICAM-1, worsening as plasma 25-hydroxyvitamin D concentration decreased. Low 25-hydroxyvitamin D emerged as an independent risk factor for LA, potentially exacerbating the inflammatory response. These findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.

Advanced Search

Year of publication

Related authors

Related hot words

Contact Us

Links