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Volume 3 Issue 3
Jul.  2023
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Article Navigation >  Frigid Zone Medicine  > 2023  >  3(3): 186-192
Xiaowei Wan, Qiuhai Qin, Ruitang Xie, Xin Li, Min Su. Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers[J]. Frigid Zone Medicine, 2023, 3(3): 186-192. doi: 10.2478/fzm-2023-0023
Citation: Xiaowei Wan, Qiuhai Qin, Ruitang Xie, Xin Li, Min Su. Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers[J]. Frigid Zone Medicine, 2023, 3(3): 186-192. doi: 10.2478/fzm-2023-0023
shu

Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers

doi: 10.2478/fzm-2023-0023
  • 1.

    Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Guilin 541004, China

  • 2.

    Department of Surgery, Ⅱ. The People's Hospital of Gangbei District, Guigang 537100, China

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  • Corresponding author: Xin Li, E-mail address: xin@glmc.edu.cn; Min Su, E-mail address: college_sumin@126.com
  • Received Date: 2022-01-05
  • Accepted Date: 2022-09-08
    • Available Online: 2023-07-25
    Abstract
  •   Background   In some developing countries, people have little knowledge about the causes of diabetic foot ulcers. Therefore, public health education for patients on these conditions is a prerequisite for effective pharmacological treatment. Diabetic foot ulcers are a complex symptom of diabetes and are hard to cure due to the lack of efficacious medicine and alternative treatment approaches. Vitamin A (VA) is known to have potent biological functions, including skin repair and immunoregulation. However, the potential pharmacological effects and molecular mechanisms of VA on foot ulcers are still to be discovered.   Methods   By using bioinformatic/computational analyses, including network pharmacology, gene ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis, we aimed to identify and reveal the pharmacological targets, molecular mechanisms, biological functions, and signaling pathways of VA in the treatment of diabetic foot ulcers.   Results   A total of 66 intersection genes were identified as candidate targets of VA, which are related to diabetic foot ulcers. Therein, 18 core genes/targets, namely JUN, MAPK1, THRB, MAPK14, MTNR1B, CXCR3, ESR1, AR, HDAC1, IL-10, CNR1, DRD2, EGFR, ADRA2A, CCND1, RXRB, RARA , and RXRA , were further identified. Furthermore, the biological processes, cell components, and molecular functions which may underlie the effects of VA against diabetic foot ulcers were characterized.   Conclusion   Based on our findings, we concluded that the pharmacological effects of VA on diabetic foot ulcers primarily involve the promotion of cellular regeneration and proliferation and the inhibition of inflammatory response. The core genes/targets may potentially serve as promising biomarkers for the diagnosis of diabetic foot ulcers.

     

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