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Volume 2 Issue 2
Apr.  2022
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Article Navigation >  Frigid Zone Medicine  > 2022  >  2(2): 103-108
Yan Liu, Xiaohui Rong, Yuanhang Chang, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang. Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.[J]. Frigid Zone Medicine, 2022, 2(2): 103-108. doi: 10.2478/fzm-2022-0014
Citation: Yan Liu, Xiaohui Rong, Yuanhang Chang, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang. Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.[J]. Frigid Zone Medicine, 2022, 2(2): 103-108. doi: 10.2478/fzm-2022-0014
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Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.

doi: 10.2478/fzm-2022-0014
  • 1.

    Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China

  • 2.

    Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China

More Information
  • Corresponding author: Haixue Kuang, E-mail: hxkuang@yahoo.com; Bingyou Yang, E-mail: ybywater@163.com
  • Received Date: 2020-12-22
  • Accepted Date: 2021-10-12
    • Available Online: 2022-04-30
    Abstract
  •   Objective  The fruit stalk of Schisandra chinensis (Turcz.) Baill. (S. chinensis) has been found to contain bioactive components similar to the fruit of S. chinensis. Here, we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity, which were isolated from the fruit stalk of S. chinensis.  Methods  The chemical components of ethyl acetate extract from 70% ethanol extract from S. chinensis fruit stalk were separated, purified, and identified by liquid chromatography methods (silica gel, ODS, HPLC) and extensive spectroscopic analyses (NMR, IR, UV, MS, CD).  Results  Two new nortriterpenoids, schilancitrilactone M and 25-hydroxyl schindilactone D (1 and 2), along with ten known nortriterpenoids (3-12) were isolated from the fruit stalk of S. chinensis. The isolated compounds were tested for their cytotoxic activities against MGC-803 cells, and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01, 11.77, and 2.74 μmol/L, respectively.  Conclusion  Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S. chinensis for the first time. Among them, compounds 6-8 showed significant anti-gastric cancer activities. We postulated that the fruit stalk of S. chinensis could be used as an anti-gastric cancer drug.

     

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    • References(14)
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