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Volume 5 Issue 3
Jul.  2025
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Article Navigation >  Frigid Zone Medicine  > 2025  >  5(3): 170-179
Xiqing Zhu, Dali Li, Shanshan Liang, Huaxing Wu, Haibin Song. Prognostic value of combined lymphocyte-to-monocyte ratio and cancer antigen 724 in patients with proximal gastric cancer residing in extremely cold regions[J]. Frigid Zone Medicine, 2025, 5(3): 170-179. doi: 10.1515/fzm-2025-0020
Citation: Xiqing Zhu, Dali Li, Shanshan Liang, Huaxing Wu, Haibin Song. Prognostic value of combined lymphocyte-to-monocyte ratio and cancer antigen 724 in patients with proximal gastric cancer residing in extremely cold regions[J]. Frigid Zone Medicine, 2025, 5(3): 170-179. doi: 10.1515/fzm-2025-0020
shu

Prognostic value of combined lymphocyte-to-monocyte ratio and cancer antigen 724 in patients with proximal gastric cancer residing in extremely cold regions

doi: 10.1515/fzm-2025-0020
  • 1.

    Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150000, China

  • 2.

    Emergency Department, Heilongjiang Provincial Hospital, Harbin 150000, China

  • 3.

    Harbin Center for Disease Control and Prevention, Harbin 150000, China

  • 4.

    Endoscope Department, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150000, China

Funds:

the Postdoctoral Scientific Research Development Fund of Heilongjiang Province, 2020 LBH-Q20157

More Information
  • Corresponding author: Huaxing Wu, E-mail: 107178265@qq.com; Haibin Song, E-mail: 601484@hrbmu.edu.cn
  • Received Date: 2024-08-11
  • Accepted Date: 2025-01-20
    • Available Online: 2025-07-01
    Abstract
  •   Background  This study aimed to evaluate the prognostic value of the lymphocyte-to-monocyte ratio (LMR) and cancer antigen 724 (CA724) in patients with proximal gastric cancer residing in cold climate regions.  Methods  A retrospective analysis was conducted on 313 patients diagnosed with proximal gastric cancer in cold climate regions between 2014 and 2017. Preoperative hematological markers, including LMR and CA724, were assessed. Receiver operating characteristic (ROC) curves were used to determine optimal cutoff values, which were then combined to form the LMR + CA724 score. Statistical analyses included Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards regression.  Results  A high preoperative LMR + CA724 score was significantly associated with older age, advanced pTNM stage, vascular invasion, and elevated levels of NMPVR, NMR, and AAR. The LMR + CA724 score demonstrated a higher area under the curve (AUC) compared to LMR or CA724 alone. Multivariate analysis identified pTNM stage, Borrmann type, histological type, and the LMR + CA724 score as independent prognostic factors for overall survival (OS). A nomogram incorporating these four variables achieved an AUC of 0.817, indicating strong predictive performance.  Conclusion  The LMR + CA724 score is a reliable and independent prognostic indicator for patients with proximal gastric cancer in cold climate regions. Its integration into clinical practice may support treatment planning and long-term management by enhancing personalized care. Further prospective studies are warranted to validate these findings in broader and more diverse patient populations.

     

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