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Volume 5 Issue 3
Jul.  2025
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Article Navigation >  Frigid Zone Medicine  > 2025  >  5(3): 141-146
Xinnan Ma, Rui Zhang, Yonghou Zhao, Xin Zhang. Risk factors for deep vein thrombosis following total hip arthroplasty in elderly patients with femoral neck fractures during winter[J]. Frigid Zone Medicine, 2025, 5(3): 141-146. doi: 10.1515/fzm-2025-0017
Citation: Xinnan Ma, Rui Zhang, Yonghou Zhao, Xin Zhang. Risk factors for deep vein thrombosis following total hip arthroplasty in elderly patients with femoral neck fractures during winter[J]. Frigid Zone Medicine, 2025, 5(3): 141-146. doi: 10.1515/fzm-2025-0017
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Risk factors for deep vein thrombosis following total hip arthroplasty in elderly patients with femoral neck fractures during winter

doi: 10.1515/fzm-2025-0017
  • 1.

    Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

  • 2.

    Department of Orthopedic Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin 150040, China

  • 3.

    Department of Neurology, Heilongjiang Mental Hospital, Harbin 150036, China

  • 4.

    Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Funds:

the Youth TCM scientific research Project of Heilongjiang Province TCM Administration ZHY2024-283

the Health and Family Planning Commission of Heilongjiang Province 20240404070039

Heilongjiang Postdoctoral Fund LBH-Z23257

the Innovative Science Research Fund of Harbin Medical University (also known as Heilongjiang Provincial University's Project of Graduate Scientific Research Business Fees) 2024, Xin Zhang

the Postdoctoral Program of Heilongjiang Province LBH-Z23234

More Information
  • Corresponding author: Yonghou Zhao, E-mail: 3350597015@qq.com; Xin Zhang, E-mail: 154762550@qq.com
  • Received Date: 2024-03-01
  • Accepted Date: 2024-12-26
    • Available Online: 2025-07-01
    Abstract
  •   Objective  To investigate the risk factors for deep vein thrombosis (DVT) following total hip arthroplasty in elderly patients with femoral neck fractures during the winter.  Methods  A total of 162 patients who underwent total hip arthroplasty were categorized based on the development of DVT within 7 days postoperatively: 28 patients formed the DVT group and 134 patients the non-DVT group. Collected data included age, gender, history of glucocorticoid use, diabetes, hypertension, body mass index (BMI), triglyceride (TG) levels, cholesterol (CHOL) levels at admission, operative time, and postoperative bed rest duration. D-dimer (D-D) and fibrinogen (Fg) levels, along with the D-D/Fg ratio, were recorded on the first postoperative day. Group comparisons were performed using t-tests. Logistic regression analysis was conducted to identify independent risk factors, and the predictive value of these factors was evaluated using receiver operating characteristic (ROC) curve analysis.  Results  In the DVT group, 18 patients had diabetes. Levels of TG (1.78 ± 0.44 mmol/L), CHOL (4.70 ± 1.84 mmol/L), D-D (0.40 ± 0.17 mg/L), and the D-D/Fg ratio (0.24 ± 0.07) were significantly higher than in the non-DVT group (P < 0.05). Logistic regression identified TG, CHOL, D-D, and the D-D/Fg ratio as independent risk factors for DVT, with odds ratios of 0.987, 2.395, 0.8, 4.992, and 9.004, respectively (P < 0.05). ROC curve analysis yielded areas under the curve (AUCs) of 0.715, 0.69, 0.614, and 0.726 for TG, CHOL, D-D, and the D-D/Fg ratio, respectively. Sensitivities were 0.643, 0.500, 0.429, and 0.857, and specificities were 0.694, 0.978, 0.918, and 0.537, respectively.  Conclusion  Elevated levels of TG, CHOL, D-D, and the D-D/Fg ratio are independent risk factors for DVT following total hip arthroplasty in elderly patients. Among these, the D-D/Fg ratio demonstrated the highest sensitivity and may serve as an effective marker for early-stage DVT screening.

     

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