Volume 5 Issue 2
Aug.  2025
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Jan Mohammad Omar, Yihui Liu. Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation[J]. Frigid Zone Medicine, 2025, 5(2): 126-127. doi: 10.1515/fzm-2025-0015
Citation: Jan Mohammad Omar, Yihui Liu. Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation[J]. Frigid Zone Medicine, 2025, 5(2): 126-127. doi: 10.1515/fzm-2025-0015

Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation

doi: 10.1515/fzm-2025-0015
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  • Corresponding author: Yihui Liu, E-mail: 502986473@qq.com
  • Received Date: 2025-07-04
  • Accepted Date: 2025-07-11
  • Available Online: 2025-08-21
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  • [1]
    Davidson J W, Jain R, T Kizzar T, et al. Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero) phosphate lipids by phospholipase A2 group XV. Cell Metab, 2025; 37(6): 1413-1425 e6. doi: 10.1016/j.cmet.2025.04.015
    [2]
    Showalter M R, Berg A L, Nagourney A, et al. The emerging and diverse roles of bis(monoacylglycero) phosphate lipids in cellular physiology and disease. Int J Mol Sci, 2020; 21(21): 8067. doi: 10.3390/ijms21218067
    [3]
    Grabner G F, Fawzy N, Schreiber R, et al. Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice. J Lipid Res, 2020; 61(7): 995-1003. doi: 10.1194/jlr.RA119000516
    [4]
    Settembre C, de Cegli R, G Mansueto, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol, 2013; 15(6): 647-658. doi: 10.1038/ncb2718
    [5]
    Nyame K, Xiong J, Alsohybe H N, et al. PLA2G15 is a lysosomal BMP hydrolase and its targeting ameliorates lysosomal disease. Nature, 2025; 642(8067): 474-483. doi: 10.1038/s41586-025-08942-y
    [6]
    Boland S, Swarup S, Ambaw Y A, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun, 2022; 13(1): 5924. doi: 10.1038/s41467-022-33500-9
    [7]
    Kirkegaard T, Roth A G, Petersen N H, et al. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature, 2010; 463(7280): 549-553. doi: 10.1038/nature08710
    [8]
    Zhang S, Williams K J, Verlande-Ferrero A, et al. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res, 2024; 65(2): 100434. doi: 10.1016/j.jlr.2023.100434
    [9]
    Karpe F, Pinnick K E. Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes. Nat Rev Endocrinol, 2015; 11(2): 90-100. doi: 10.1038/nrendo.2014.185
    [10]
    Herzig S, Shaw R J. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol, 2018; 19(2): 121-135. doi: 10.1038/nrm.2017.95
    [11]
    Medina D L, Di Paola S, Peluso I, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol, 2015; 17(3): 288-299. doi: 10.1038/ncb3114
    [12]
    Decressac M, Mattsson B, Weikop P, et al. TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A, 2013; 110(19): E1817-1826. doi: 10.1073/pnas.1305623110
    [13]
    Alvarez-Valadez K, Sauvat A, Diharce J, et al. Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death. Autophagy, 2025; 21(5): 934-956. doi: 10.1080/15548627.2024.2440842
    [14]
    Anderson D MG, Ablonczy Z, Koutalos Y, et al. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Sci Rep, 2017; 7(1): 17352. doi: 10.1038/s41598-017-17402-1
    [15]
    Glukhova A, Hinkovska-Galcheva V, Kelly R, et al. Structure and function of lysosomal phospholipase A2 and lecithin: cholesterol acyltransferase. Nat Commun, 2015; 6: 6250. doi: 10.1038/ncomms7250
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