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Volume 4 Issue 2
Apr.  2024
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Article Navigation >  Frigid Zone Medicine  > 2024  >  4(2): 102-109
Jiaxin Guan, Lu Gan, Chaoqi Yan, Boyu Hou, Ying Fan. Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China[J]. Frigid Zone Medicine, 2024, 4(2): 102-109. doi: 10.1515/fzm-2024-0011
Citation: Jiaxin Guan, Lu Gan, Chaoqi Yan, Boyu Hou, Ying Fan. Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China[J]. Frigid Zone Medicine, 2024, 4(2): 102-109. doi: 10.1515/fzm-2024-0011
shu

Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

doi: 10.1515/fzm-2024-0011
  • 1.

    Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

  • 2.

    The Physical examination center of the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Funds:

the National Natural Science Foundation of Heilongjiang Province of China LH2020H051

Key R&D projects of Natural Science Foundation of Heilongjiang Province 2023ZX06C03

Foundation of Harbin Science Technology Bureau of China 2014RFQGJ042

More Information
  • Corresponding author: Ying Fan, fanyingyan@163.com
  • Received Date: 2023-11-12
  • Accepted Date: 2024-04-25
    • Available Online: 2024-04-01
    Abstract
  •   Background and objective  Commonly plaguing in the frigid zone of the world, vitamin D deficiency, as indicated by low levels of 25-hydroxyvitamin D, exacerbated inflammatory responses and impaired endothelial function. Leukoaraiosis (LA) is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory responses. This study aimed to investigate the impact of vitamin D on the severity of LA.  Methods  Patients with LA were categorized based on 3.0 T brain MRI findings into mild (N = 43), moderate (N = 40), or severe groups (N = 29) using the Fazekas scale (scoring 1-6). A control group consisting of 41 healthy individuals was included. Serum fibrinogen C, homocysteine, plasma 25-hydroxyvitamin D, and intercellular cell adhesion molecule-1 (ICAM-1) levels were measured using ELISA.  Results  All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group, with a more pronounced decrease observed as LA severity increased. Low plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA (P < 0.05) according to Multiple logistic regression analysis. Additionally, a negative association was observed between 25-hydroxyvitamin D and vascular inflammatory factor ICAM-1.  Conclusions  Disease severity positively correlated with levels of the inflammatory marker ICAM-1, worsening as plasma 25-hydroxyvitamin D concentration decreased. Low 25-hydroxyvitamin D emerged as an independent risk factor for LA, potentially exacerbating the inflammatory response. These findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.

     

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    • References(39)
  • [1]
    Wardlaw J M, Smith E E, Biessels G J, et al. Neuroimaging standards neurodegeneration. Lancet Neurol, 2013; 12(8): 822-838. doi: 10.1016/S1474-4422(13)70124-8
    [2]
    Cannistraro R J, Badi M, Eidelman B H, et al. CNS small vessel disease: A clinical review. Neurology, 2019; 92(24): 1146-1156. doi: 10.1212/WNL.0000000000007654
    [3]
    Su N, Zhai F F, Zhou LX, et al. Cerebral small vessel disease burden is associated with motor performance of lower and upper extremities in community-dwelling populations. Front Aging Neurosci, 2017; 9: 313. doi: 10.3389/fnagi.2017.00313
    [4]
    Zhi N, Zhang L, Wang Y, et al. Modified cerebral small vessel disease score is associated with vascular cognitive impairment after lacunar stroke. Aging (Albany NY), 2021; 13(7): 9510-9521. doi: 10.18632/aging.202438
    [5]
    van der Holst H M, van Uden I W, Tuladhar A M, et al. Factors associated with 8-year mortality in older patients with cerebral small vessel disease: the radboud university nijmegen diffusion tensor and magnetic resonance cohort (RUN DMC) study. JAMA Neurol, 2016; 73(4): 402-409. doi: 10.1001/jamaneurol.2015.4560
    [6]
    Wardlaw J M, Chappell F M, Valdes Hernandez M D C, et al. White matter hyperintensity reduction and outcomes after minor stroke. Neurology, 2017; 89(10): 1003-1010. doi: 10.1212/WNL.0000000000004328
    [7]
    Jiaerken Y, Luo X, Yu X, et al. Microstructural and metabolic changes in the longitudinal progression of white matter hyperintensities. J Cereb Blood Flow Metab, 2019; 39(8): 1613-1622. doi: 10.1177/0271678X18761438
    [8]
    Howard D P J, Gaziano L, Rothwell P M, et al. Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis. Lancet Neurol, 2021; 20(3): 193-202. doi: 10.1016/S1474-4422(20)30484-1
    [9]
    Bernbaum M, Menon B K, Fick G, et al. Reduced blood flow in normal white matter predicts development of leukoaraiosis. J Cereb Blood Flow Metab, 2015; 35(10): 1610-1615. doi: 10.1038/jcbfm.2015.92
    [10]
    Promjunyakul N O, Dodge H H, Lahna D, et al. Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time. Neurology, 2018; 90(24): e2119-e2126. doi: 10.1212/WNL.0000000000005684
    [11]
    Philips T Rothstein J D. Oligodendroglia: metabolic supporters of neurons. J Clin Invest, 2017; 127(9): 3271-3280. doi: 10.1172/JCI90610
    [12]
    Sargurupremraj M, Suzuki H, Jian X, et al. Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun, 2020; 11(1): 6285. doi: 10.1038/s41467-020-19111-2
    [13]
    Gardener H, Caunca M, Dong C, et al. Ideal cardiovascular health and biomarkers of subclinical brain aging: the northern Manhattan study. J Am Heart Assoc, 2018; 7(16): e009544. doi: 10.1161/JAHA.118.009544
    [14]
    Shu Z, Xu Y, Shao Y, et al. Radiomics from magnetic resonance imaging may be used to predict the progression of white matter hyperintensities and identify associated risk factors. Eur Radiol, 2020; 30(6): 3046-3058. doi: 10.1007/s00330-020-06676-1
    [15]
    Shu Z Y, Shao Y, Xu Y Y, et al. Radiomics nomogram based on MRI for predicting white matter hyperintensity progression in elderly adults. J Magn Reson Imaging, 2020; 51(2): 535-546. doi: 10.1002/jmri.26813
    [16]
    Whitman G T, Tang Y, Lin A, et al. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology, 2001; 57(6): 990-994. doi: 10.1212/WNL.57.6.990
    [17]
    Lin L, Zhang Y, Zeng Q, et al. Atherosclerosis, inflammatory factor changes, cognitive disorder and vascular endothelial functions in patients with different grades of leukoaraiosis. Clin Hemorheol Microcirc, 2019; 73(4): 591-597. doi: 10.3233/CH-190597
    [18]
    Xue J, Wu Z, Gong S, et al. High-dose atorvastatin improves vascular endothelial function in patients with leukoaraiosis. J Clin Lab Anal, 2020; 34(3): e23081. doi: 10.1002/jcla.23081
    [19]
    Arba F, Giannini A, Piccardi B, et al. Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke. Eur Stroke J, 2019; 4(2): 119-126. doi: 10.1177/2396987318805905
    [20]
    Cao G Z, Hou J Y, Zhou R, et al. Single-cell RNA sequencing reveals that VIM and IFITM3 are vital targets of Dengzhan Shengmai capsule to protect against cerebral ischemic injury. J Ethnopharmacol, 2023; 311: 116439. doi: 10.1016/j.jep.2023.116439
    [21]
    Johnson C R, Thacher T D. Vitamin D: immune function, inflammation, for research into small vessel disease and its contribution to ageing and infections and auto-immunity. Paediatr Int Child Health, 2023; 43(4): 29-39. doi: 10.1080/20469047.2023.2171759
    [22]
    Zhou A, Hypponen E. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study. Int J Epidemiol, 2023; 52(1): 260-271. doi: 10.1093/ije/dyac087
    [23]
    Jin D, Zhu D M, Hu H L, et al. Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein. Nutr Metab (Lond), 2020; 17: 57. doi: 10.1186/s12986-020-00455-x
    [24]
    Meng J, Xu Y R, Miao X H, et al. A retrospective study on serum 25 (OH) D level of the sampled population in a hospital in Heilongjiang province. Chinese Journal of Osteoporosis, 2022; 28(1): 62-69.
    [25]
    Li L, Zhao YX, Sun G W, et al. Analysis of the content of adult 25-hydroxyvitamin D in Heilongjiang Province. Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic), 2018; 6(27): 187, 190.
    [26]
    Fazekas F, Deisenhammer F, Strasser-Fuchs S, et al. Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Austrian Immunoglobulin in Multiple Sclerosis Study Group. Lancet, 1997; 349(9052): 589-593. doi: 10.1016/S0140-6736(96)09377-4
    [27]
    Guan J, Yan C, Gao Q, et al. Analysis of risk factors in patients with leukoaraiosis. Medicine (Baltimore), 2017; 96(8): e6153. doi: 10.1097/MD.0000000000006153
    [28]
    Leung L Y, Bartz T M, Rice K, et al. Blood pressure and heart rate measures associated with increased risk of covert brain infarction and worsening leukoaraiosis in older adults. Arterioscler Thromb Vasc Biol, 2017; 37(8): 1579-1586. doi: 10.1161/ATVBAHA.117.309298
    [29]
    Levit A, Hachinski V, Whitehead S N. Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease. Geroscience, 2020; 42(2): 445-465. doi: 10.1007/s11357-020-00164-6
    [30]
    Drieu A, Lanquetin A, Levard D, et al. Alcohol exposure-induced neurovascular inflammatory priming impacts ischemic stroke and is linked with brain perivascular macrophages. JCI Insight, 2020; 5(4): e129226. doi: 10.1172/jci.insight.129226
    [31]
    Bustamante A, Lopez-Cancio E, Pich S, et al. Blood biomarkers for the early diagnosis of stroke: the stroke-chip study. Stroke, 2017; 48(9): 2419-2425. doi: 10.1161/STROKEAHA.117.017076
    [32]
    Bembenek J P, Niewada M, Siudut J, et al. Fibrin clot characteristics in acute ischaemic stroke patients treated with thrombolysis: the impact on clinical outcome. Thromb Haemost, 2017; 117(7): 1440-1447. doi: 10.1160/TH16-12-0954
    [33]
    Ashouri R, Fangman M, Brielmaier J, et al. Nutritional supplementation of naturally occurring vitamin D to improve hemorrhagic stroke outcomes. Front Neurol, 2021; 12: 670245. doi: 10.3389/fneur.2021.670245
    [34]
    Fu Y, Yan Y. Emerging role of immunity in cerebral small vessel disease. Front Immunol, 2018; 9: 67. doi: 10.3389/fimmu.2018.00067
    [35]
    Shi L, Zhang Q, Song S N, et al. Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study. Medicine (Baltimore), 2021; 100(18): e25826. doi: 10.1097/MD.0000000000025826
    [36]
    Miao J, Bachmann K N, Huang S, et al. Effects of vitamin D supplementation on cardiovascular and glycemic biomarkers. J Am Heart Assoc, 2021; 10(10): e017727. doi: 10.1161/JAHA.120.017727
    [37]
    An J H, Cho D H, Lee G Y, et al. Effects of vitamin D supplementation on CD4(+) T cell subsets and mtor signaling pathway in high-fat-diet-induced obese mice. Nutrients, 2021; 13(3): 796. doi: 10.3390/nu13030796
    [38]
    Boontanrart M, Hall S D, Spanier J A, et al. Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism. J Neuroimmunol, 2016; 292: 126-136. doi: 10.1016/j.jneuroim.2016.01.015
    [39]
    Evans M A, Kim H A, Ling Y H, et al. Vitamin D3 supplementation reduces subsequent brain injury and inflammation associated with ischemic stroke. Neuromolecular Med, 2018; 20(1): 147-159. doi: 10.1007/s12017-018-8484-z
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