Advancements in understanding inflammatory responses and the development of cardiovascular diseases under cold stimulation

Guanpeng Ma; Hengxuan Cai; Zhaoying Li; Rongzhe Lu; Bo Yu; Shaohong Fang

doi:10.2478/fzm-2023-0028

Advancements in understanding inflammatory responses and the development of cardiovascular diseases under cold stimulation

doi: 10.2478/fzm-2023-0028

Guanpeng Ma^{1, 2, 3},
Hengxuan Cai^{1, 2, 3},
Zhaoying Li^{1, 2, 3},
Rongzhe Lu^{1, 2, 3},
Bo Yu^{1, 2, 3},
Shaohong Fang^{1, 2, 3
, ,}

1.
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
2.
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, China
3.
National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD), Harbin Medical University, Harbin 150001, China

Funds:

National Natural Science Foundation of China 82170262

National Natural Science Foundation of China 82200546

More Information

Corresponding author: Shaohong Fang, E-mail: fangshaohong7802@163.com

摘要

Abstract: Cold stimulation has been linked to acute myocardial infarction and other cardiovascular diseases. Residents in the frigid zones, such Heilongjiang Province, experience a higher incidence of adverse cardiovascular events during winter, posing a significant health threat and increasing the overall medical burden. Cold stimulation serves as an detrimental stressor, inducing inflammation in the body. Therefore, understanding the role of inflammatory responses induced by cold stimulation in the occurrence and development of cardiovascular diseases is of paramount importance. Given the impact of cold on inflammation in cardiovascular diseases and the expanding array of anti-inflammatory methods for the treatment of cardiovascular diseases, delving into the inflammatory responses mediated by can significantly complement cardiovascular disease management. This review explorest the synergistic relationship between cold stimulation and inflammation induction, elucidating how this interplay influences the occurrence and progression of cardiovascular diseases.
- cold stimulation /
- inflammatory response /
- cardiovascular diseases /
- cold exposure /
- inflammatory factors

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Figure 1. Schematic presentation of potential mechanisms underlying inflammation and cardiovascular conditions induced by low ambient temperature

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