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Prospects of DNA microarray application in management of chronic obstructive pulmonary disease: A systematic review
doi: 10.2478/fzm-2023-0002
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Abstract: Chronic obstructive pulmonary disease (COPD) is incurable chronic disease which kills 3.3 million each year worldwide. Number of global cases of COPD is steadily rising alongside with life expectancy, disproportionally hitting middle-income countries like Russia and China, in such conditions, new approaches to the COPD management are desperately needed. DNA microarray technology is a powerful genomic tool that has the potential to uncover underlying COPD biological alteration and brings up revolutionized treatment option to clinicians. We executed systematic review studies of studies published in last 10 years regarding DNA microarray application in COPD management, with complacence to PRISMA criteria and using PubMed and Medline data bases as data source. Out of 920 identified papers, 39 were included in the final analysis. We concluded that Genome-wide expression profiling using DNA microarray technology has great potential in enhancing COPD management. Current studied proofed this method is reliable and possesses many potential applications such as individual at risk of COPD development recognition, early diagnosis of disease, COPD phenotype identification, exacerbation prediction, personalized treatment optioning and prospect of oncogenesis evaluation in patients with COPD. Despite all the proofed benefits of this technology, researchers are still in the early stage of exploring it's potential. Therefore, large clinical trials are still needed to set up standard for DNA microarray techniques usage implementation in COPD management guidelines, subsequently giving opportunity to clinicians for controlling or even eliminating COPD entirely.
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Key words:
- chronic obstructive pulmonary disease /
- biomarker /
- expression profiling /
- DNA microarray
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Table 1. Summary of identified potential genes for COPD diagnosis
Authors Publication year DNA microarray platform Sampling source Significant genes detected Bhattacharya et al.[17] 2011 Affymetrix Peripheral blood, lung tissue RP9, NAPE-PLD, ARID2, STX17, FOXP1, SESN1 Bahr et al.[18] 2013 Affymetrix Peripheral blood, GSE42057 ASAH1, FOXP1, TLR8, VNN2 Wei et al.[19] 2015 Affymetrix GSE29133 HMGCS2, FABP6, TAP1, HLA-A, HLA-DOB, HLA-F Boudewijn et al.[20] 2017 Affymetrix Nasal epithelial brushings NPHP1, CFAP206, CCDC113, MUC1, CREB3L1, DSP Yao et al.[21] 2019 Aglient Peripheral blood HBEGF, DIO2, CLCN3 Rogers et al.[22] 2019 Affymetrix, Aglient Peripheral blood DUSP7, GPR15, PLD1, RPS4Y1, FCGR1B, TCF7 Huang et al.[23] 2019 Affymetrix Lung tissue CX3CR1, PPBP, PTGS2, FPR1, FPR2, VCAM1, S100A12, ARG1, EGR1, CD163, FGG, ORM1, S100A8, S100A9 Yu et al.[24] 2021 Affymetrix Lung tissue MTHFD2, KANK3, GFPT2, PHLDA1, HS3ST2, FGG, RPS4Y1 Winter et al.[25] 2021 Affymetrix Sputum, peripheral blood TPSB2, CPA3, KIT, GATA2, SOCS2, ENO2, GPR56, HDC COPD, chronic obstructive pulmonary disease. 
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