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Prevention of osteoporotic fracture: from skeletal and non-skeletal perspectives
doi: 10.2478/fzm-2022-0029
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Abstract:
With the global population aging, especially in China, the prevention and management of osteoporotic fragility fractures has become increasingly important. Bone mineral density (BMD) is an important index of osteoporotic fracture risk, which has become aroutine measurement inclinical practice and thus formed the cornerstone in monitoring treatment efficacy of osteoporosis. In the past 30 years, several pharmacologic therapies have been developed to increase BMD and reduce osteoporotic fractures, especially vertebral fractures. However, the management of nonvertebral fractures and hip fractures remains challenging as low BMD is only one of the multi-factors for these conditions. Hip fractures mainly result from a fall and its incidence is higher in the frigid zone due to low temperature affecting neuromuscular function and high latitude with less sunlight, the conditions rendering less active vitamin D conversion, apart from increased falling. In this paper, we focus on two therapeutic strategies targeting both skeletal and non-skeletal factors, that is, Tai Chi (TC) exercise for improving balance and "kidney-tonifying" traditional Chinese medicine (TCM) against muscle atrophy. TC is a mind-body exercise that has the potential as an effective and safe intervention for preventing fall-related fractures in the elderly. This makes it a promising and feasible physical activity for the elderly in frigid zone to prevent osteoporotic fractures. Several TCM formula popular in northeast of China within frigid zone are also introduced. They are reportedly effective in maintaining or improving BMD and muscle strength with the potential of reducing osteoporotic fracture. However, more rationally designed vigorous basic investigations and prospective clinical trials are highly desired to validate and consolidate the preliminary observations in the future.
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Key words:
- osteoporotic fracture /
- sarcopenia /
- Traditional Chinese Medicine /
- Tai Chi exercise
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Table 1. Summary of studies evaluating impact of Tai Chi on BMD, muscle strength and fall in elderly
Study Study Design(Duration) Study Population(Age) Interventions and Sample Size Outcomes Measured Results Qin et al.[36] Case-control study (12 months) Postmenopausal women (50-59 years) Long-term TC practitioners (over 4 years experience)(n=17); Age-matched sedentary controls (n=17) BMD of lumbar spine and proximal femur, and distal tibia Significantly greater BMD in lumbar spine, proximal femur, and tibia in TC vs. control at baseline. Reduced rates of trabecular BMD loss of the ultradistal tibia and of cortical BMD loss of the distaltibial diaphysis in TC. Qin et al.[37] Cross-sectional study Postmenopausal women (55.9 ± 3.1 years) TC: more than 3 h/week (n=48); Age-matched sedentary controls (n=51) BMD of lumbar spine and proximal femur, quadriceps strength, flexibility, balance Significantly greater BMD in lumbar spine and some regions of femur (greater trochanter, Ward's area) in TC vs. control.
Greater quad strength and balance in TC vs. controlChan et al.[42] Age-matched RCT (12 months) Postmenopausal women (54.0 ± 3.5 years) TC: 5 sessions/wk, 45 min (n=67); Age-matched sedentary controls (n=65) BMD of lumbar spine and proximal femur, and of distal tibia Significant retardation of bone loss in both trabecular and cortical compartments of the distal tibia in the TC vs. control.
Four fracture cases, including 3 subjects in the control group and 1 in the TC group.Wayne et al.[44] RCT (9 months) Postmenopausal osteopenic women (45-70 years) TC: 99.5h TC training (n=43);
UC: n=43BMD of the proximal femur and lumbar spine, serum markers of bone resorption and formation, and quality of life. Quiet standing fall-predictive sway parameters and clinical balance tests in a subsample Femoral neck BMD were significantly higher in TC (completed ≥ 75% training) vs. UC. In the Usual Care group, average serum concentrations of CTX and OC increased by 4.3% and 6.3%, respectively, while in the TC group, CTX and OC decreased by-7.1% and -5.1%, respectively. More favorable changes in bone physical domains of quality of life in TC vs. UC. Significantly improved in sway parameters in TC vs. UC. Shen et al.[45] RCT (6 months) Postmenopausal osteopenic women (57.5 ± 6.9 years) Placebo: 500 mg medicinal starch daily (n=44);
GTP: 500 mg of green tea polyphenols (n=47);
Placebo + TC: 1h TC class/week, 500 mg medicinal starch daily (n=42);
GTP + TC: 1h TC class/week, 500 mg of green tea daily (n=38)blood and urine biomarker analyses, and muscle strength At 6 months, significant increases in the change of BALP/TRAP ratio in TC group. Muscle strength significantly improved due to GTP, TC, and GTP + TC interventions at 6 months. Li et al.[53] Controlled Clinical Trial (16 weeks) elderly individuals (aged 60 years, 20 men and 20 women) TC: supervised TC exercise (11 men and 11 women);
Control: general education (9 men and 9 women)maximum concentric strength and dynamic endurance of the knee flexors and the extensors, the maximum concentric strength of the ankle plantar flexors and dorsiflexors, onset latency to sudden perturbations in the rectus femoris, semitendinosus, gastrocnemius, and anterior tibialis muscles Significantly greater muscle strength of the knee flexors in TC group vs. control.
Significantly shorter semitendinosus muscle latency in TC vs. control (P=0.042).Song et al.[55] RCT (4, 8, 12 months) Urban elderly women (years) TC: 40min TC exercise/d (n=35);
Control I: 40min dance/d (n=35);
Control Ⅱ: 40min brisk walking/d (n=35)lower limb skeletal muscle mass, lower limb muscle strength, BMD and balance function At 4 months, most of the study indexes in the control group I and group Ⅱ are improved significantly. The study indexes in three groups show no significant difference.
At 8 months, relevant study indexes of the subjects in the three groups are significantly improved.
The effect in the TC group is more obvious and is better vs. control Ⅱ.
At 12 months, the effect of the TC group is improved significantly vs. control I and Ⅱ (P < 0.05 or P < 0.01).Taylor-Piliae et al.[56] 2-phase RCT (12 months) Healthy adults (69 ± 5.8 years) TC: one 45min TC class/week, encourage daily practice (n=37);
WE: 3 times/week, incorporated endurance, resistance/strength, and flexibility exercises (n=39);
C: healthy aging classes attention-control group (n=56)Physical functioning included balance, strength, flexibility, and cardiorespiratory endurance.
Cognitive functioning included semantic fluency and digit-spantests.At 6 months, WE had greater improvements in upper body flexibility than TC and C. TC had greater improvements in balance and a cognitive-function measure than WE and C. The differential cognitive-function improvements observed in TC were maintained through 12 months. Guo et al.[57] Cross-sectional study Elderly volunteers (64.5 ± 8.48 years) TC: average 9.64 years TC exercise (n=16);
Control: sedentary controls (n=9)static balance test, ankle proprioception test, and concentric and eccentric knee extensor and flexor muscle strength tests TC group performed better than the Control group in balance, proprioception, and muscle strength of lower extremity. BMD, bone mineral density; TC, Tai Chi; UC, usual care; CTX, C-terminal collagen cross-link; OC, osteocalcin; BALP, bone-specific alkaline phosphatase; TRAP: tartrate-resistant acid phosphatase; GTP: green tea polyphenols group; WE: western exercise group; C: control group 
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Table 2. Selected studies on the effects of ginseng, deer antler, epimedium, and baill or its main components in muscle and bone
Herbs Study Population Treatment Function Key finds Panax ginseng extract Kim et al.[108] Fourteen healthy men (22-28 years) Drug: 6 g/d for 8 weeks (n=7)
Control: placebo /d for 8 weeks (n=7)Muscle quality ↑ Ginseng administration significantly increased exercise duration until exhaustion. American ginseng Lin et al.[80] Twelve physically active men (22.4 ± 1.7years) Drug: 1.6 g/d for 4 weeks (n=6)
Control: placebo /d for 4 weeks (n=6)Risk of muscle injury ↓ Ginseng alleviates eccentric exercise-induced muscle damage. Panax ginseng extract Jung et al.[68] Ninety women with osteopenia (> 40 years) H-Drug: 3 g/d for 12 weeks (n=30)
L-Drug: 1 g/d for 12 weeks (n=30)
Control: placebo /d for 12weeks (n=30)Bone formation ↑ Ginseng improved the knee arthritis symptoms with enhancement in the osteocalcin concentration and ratios of bone formation indices like deoxypyridinoline/osteocalcin. Deer Antler Extract Chen et al.[87] Six male BABL/c mice 8.2 mg/day, for 4 weeks Muscle quality ↑ Deer antler extract improves fatigue effect in skeletal muscle by altering the expression of genes related to muscle strength. Fermented deer antler extract Jang et al.[88] Eight male BALB/c mice 500 mg/kg/day, for 4 weeks Muscle quality ↑ Total average duration of swimming time of the deer antler extract group was increased. deer antler Widyowati et al. Six healthy male mice for each group 4, 8, and 12 mg/kg/day, for 4 weeks BMD ↑ Deer antler to increase trabecular bone density and calcium levels in serum. Icariin Wang et al.[97] Eight SD male rats 10 mg/kg/day, for 2 weeks. Risk of muscle injury ↓ Icariin has excellent therapeutic effects on acute blunt muscleinjury in rats by improving immunity. Icariin Zhang et al.[96] Eight Wistar male rats 45 mg/kg/day, for 3 weeks Muscle quality ↑ The exhaustive swimming times of rats in icariin group were significantly prolonged. Epimedium extract Yong et al.[93] Sixty healthy postmenopausal women (57.9 ±8.9 years) Drug: 740 mg/day for 6 weeks (n=30)
Control: placebo /d for 6 weeks (n=30)Bone formation ↑ Rise in prenylflavonoid metabolites was associated with higher levels of the bone anabolic marker BALP. Schisandra chinensis (Turcz.) Baill Cho et al.[105] Eight SD male rats 20 or 100 mg/kg, 14 times over 3 weeks. Muscle quality ↑ Schisandra chinensis (Turcz.) Baill increases the grip strength and muscle fiber size in rats. S. chinensis (Turcz.)extract Kim et al.[103] Seven SD male rats 10 mg/kg/day, for 8 weeks BMD ↑
Muscle quality ↑Baill extract increases the BMD in OVX rats and ameliorates the age-related muscle wasting. The up arrow means increase. The down arrow means decrease. SD, Sprague Dawley; BMD, bone mineral density.
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[1] Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med, 1993; 94(6): 646-650. [2] Kanis J A, McCloskey E V, Johansson H, et al. A reference standard for the description of osteoporosis. Bone, 2008; 42(3): 467-475. doi: 10.1016/j.bone.2007.11.001 [3] Johnell O, Kanis J A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int, 2006; 17(12): 1726-1733. doi: 10.1007/s00198-006-0172-4 [4] Curtis E M, van der Velde R, Moon R J, et al. Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone, 2016; 87: 19-26. doi: 10.1016/j.bone.2016.03.006 [5] Shen Z W, Wei Y X, Yu C Q, et al. Descriptive analysis of fracture hospitalization rate in adultsfrom 10 regions of China. Zhonghua Liu Xing Bing Xue Za Zhi, 2021; 42(5): 771-779. [6] Si L, Winzenberg T M, Jiang Q, et al. Projection of osteoporosisrelated fractures and costs in China: 2010-2050. Osteoporos Int, 2015; 26(7): 1929-1937. doi: 10.1007/s00198-015-3093-2 [7] Fuggle N R, Curtis E M, Ward K A, et al. Fracture prediction, imaging and screening in osteoporosis. Nat Rev Endocrinol, 2019; 15(9): 535-547. doi: 10.1038/s41574-019-0220-8 [8] Clynes M A, Harvey N C, Curtis E M, et al. The epidemiology of osteoporosis. Br Med Bull, 2020; 133(1): 105-117. [9] Blain H, Masud T, Dargent-Molina P, et al. A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement. Aging Clin Exp Res, 2016; 28(4): 797-803. doi: 10.1007/s40520-016-0588-4 [10] Wahl D A, Cooper C, Ebeling P R, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos, 2012; 7: 155-172. doi: 10.1007/s11657-012-0093-0 [11] Kanis J A, McCloskey E V, Harvey N C, et al. Intervention thresholds and the diagnosis of osteoporosis. J Bone Miner Res, 2015; 30(10): 1747-1753. doi: 10.1002/jbmr.2531 [12] Song L. Calcium and Bone Metabolism Indices. Adv Clin Chem, 2017; 82: 1-46. [13] Vilaca T, Gossiel F, Eastell R. Bone turnover markers: Use in fracture prediction. J Clin Densitom, 2017; 20(3): 346-352. doi: 10.1016/j.jocd.2017.06.020 [14] Vasikaran S, Eastell R, Bruyère O, et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int, 2011; 22(2): 391-420. doi: 10.1007/s00198-010-1501-1 [15] Saag K G, Petersen J, Brandi M L, et al. Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med, 2017; 377(15): 1417-1427. doi: 10.1056/NEJMoa1708322 [16] Cummings S R, San Martin J, McClung M R, et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med, 2009; 361(8): 756-765. doi: 10.1056/NEJMoa0809493 [17] Malouf-Sierra J, Tarantino U, García-Hernández P A, et al. Effect of teriparatide or risedronate in elderly patients with a recent pertrochanteric hip fracture: Final results of a 78-week randomized clinical trial. J Bone Miner Res, 2017; 32(5): 1040-1051. doi: 10.1002/jbmr.3067 [18] Laura I, Felicia B, Alexia C, et al. Which treatment to prevent an imminent fracture? Bone Rep, 2021; 15: 101105. doi: 10.1016/j.bonr.2021.101105 [19] Miller P D, Hattersley G, Riis B J, et al. Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial. JAMA, 2016; 316(7): 722-733. doi: 10.1001/jama.2016.11136 [20] McClung M R, Geusens P, Miller P D, et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med, 2001; 344(5): 333-340. doi: 10.1056/NEJM200102013440503 [21] Cosman F, Crittenden D B, Adachi J D, et al. Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med, 2016; 375(16): 1532-1543. doi: 10.1056/NEJMoa1607948 [22] Wainwright S A, Marshall L M, Ensrud K E, et al. Study of osteoporotic fractures research, hip fracture in women without osteoporosis. J Clin Endocrinol Metab, 2005; 90(5): 2787-2793. doi: 10.1210/jc.2004-1568 [23] Sornay-Rendu E, Munoz F, Garnero P, et al. Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res, 2005; 20(10): 1813-1819. doi: 10.1359/JBMR.050609 [24] Szulc P, Munoz F, Duboeuf F, et al. Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study. Osteoporos Int, 2005; 16(10): 1184-1192. doi: 10.1007/s00198-005-1970-9 [25] Cooper C, Melton LJ 3rd. Epidemiology of osteoporosis. Trends EndocrinolMetab, 1992; 3(6): 224-229. doi: 10.1016/1043-2760(92)90032-V [26] Parkkari J, Kannus P, Palvanen M, et al. Majority of hip fractures occur as a result of a fall and impact on the greater trochanter of the femur: a prospective controlled hip fracture study with 206 consecutive patients. Calcif Tissue Int, 1999; 65(3): 183-187. doi: 10.1007/s002239900679 [27] Stevens J A, Olson S. Reducing falls and resulting hip fractures among older women. MMWR Recomm Rep, 2000; 49(RR-2): 3-12. [28] Morris R, O'Riordan S. Prevention of falls in hospital. Clin Med (Lond), 2017; 17(4): 360-362. [29] Murphy L, Riley D, Rodgers J, et al. Effects of Tai Chi on balance, mobility, and strength among older persons participating in an osteoporosis prevention and education program. Explore (NY), 2005; 1(3): 192-193. doi: 10.1016/j.explore.2005.02.019 [30] Youm T, Koval K J, Kummer F J, et al. Do all hip fractures result from a fall? Am J Orthop (Belle Mead NJ), 1999; 28(3): 190-194. [31] Erinç S, Bozca M A, Bankaoğlu M, et al. Association of abductor hip muscle atrophy with fall-related proximal femur fractures in the elderly. Injury, 2020; 51(7): 1626-1633. doi: 10.1016/j.injury.2020.04.054 [32] You Y, Min L, Tang M, et al. Bibliometric evaluation of global Tai Chi Research from 1980-2020. Int J Environ Res Public Health, 2021; 18(11): 6150. doi: 10.3390/ijerph18116150 [33] Wu G, Liu W, Hitt J, et al. Spatial, temporal and muscle action patterns of Tai Chi gait. J Electromyogr Kinesiol, 2004; 14(3): 343-354. doi: 10.1016/j.jelekin.2003.09.002 [34] Purdie N. Tai chi to prevent falls in older adults. Br J Community Nurs, 2019; 24(11): 550-552. doi: 10.12968/bjcn.2019.24.11.550 [35] Li F, Harmer P, Eckstrom E, et al. Effectiveness of Tai Ji Quan vs multimodal and stretching exercise interventions for reducing injurious falls in older adults at high risk of falling: Follow-up analysis of a randomized clinical trial. JAMA Netw Open, 2019; 2(2): e188280. doi: 10.1001/jamanetworkopen.2018.8280 [36] Qin L, Au S, Choy W, et al. Chan, Regular Tai Chi Chuan exercise may retard bone loss in postmenopausal women: A case-control study. Arch Phys Med Rehabil, 2002; 83(10): 1355-1359. doi: 10.1053/apmr.2002.35098 [37] Qin L, Choy W, Leung K, et al. Beneficial effects of regular Tai Chi exercise on musculoskeletal system. J Bone Miner Metab, 2005; 23(2): 186-190. doi: 10.1007/s00774-004-0559-2 [38] Xiao C, Kang Y, Zhuang Y C. Effects of Tai Chi Ball on estrogen levels, bone metabolism index, and muscle strength of perimenopausal women. J Am Geriatr Soc, 2015; 63(12): 2629-2631. doi: 10.1111/jgs.13862 [39] Chow T H, Lee B Y, Ang A B F, et al. The effect of Chinese martial arts Tai Chi Chuan on prevention of osteoporosis: A systematic review. J Orthop Translat, 2018; 12: 74-84. doi: 10.1016/j.jot.2017.06.001 [40] Lui P P, Qin L, Chan K M. Tai Chi Chuan exercises in enhancing bone mineral density in active seniors. Clin Sports Med, 2008; 27(1): 75-86, viii. doi: 10.1016/j.csm.2007.09.002 [41] Wayne P M, Kiel D P, Krebs D E, et al. The effects of Tai Chi on bone mineral density in postmenopausal women: a systematic review. Arch Phys Med Rehabil, 2007; 88(5): 673-680. doi: 10.1016/j.apmr.2007.02.012 [42] Chan K, Qin L, Lau M, et al. A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women. Arch Phys Med Rehabil, 2004; 85(5): 717-722. doi: 10.1016/j.apmr.2003.08.091 [43] Hall A, Copsey B, Richmond H, et al. Effectiveness of Tai Chi for chronic musculoskeletal pain conditions: Updated systematic review and meta-analysis. Phys Ther, 2017; 97(2): 227-238. doi: 10.2522/ptj.20160246 [44] Wayne P M, Kiel D P, Buring J E, et al. Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial. BMC Complement Altern Med, 2012; 12: 7. doi: 10.1186/1472-6882-12-7 [45] Shen C L, Chyu M C, Yeh J K, et al. Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial. Osteoporos Int, 2012; 23(5): 1541-1552. doi: 10.1007/s00198-011-1731-x [46] Li F, Harmer P, Fitzgerald K, et al. Effectiveness of a therapeutic Tai Ji Quan intervention vs a multimodal exercise intervention to prevent falls among older adults at high risk of falling: A randomized clinical trial. JAMA Intern Med, 2018; 178(10): 1301-1310. doi: 10.1001/jamainternmed.2018.3915 [47] Wolf S L. From tibialis anterior to Tai Chi: biofeedback and beyond. Appl Psychophysiol Biofeedback, 2001; 26(2): 155-174. doi: 10.1023/A:1011395324622 [48] Vignaux G, Ndong J D, Perrien D S, et al. Inner ear vestibular signals regulate bone remodeling via the sympathetic nervous system. J Bone Miner Res, 2015; 30(6): 1103-1111. doi: 10.1002/jbmr.2426 [49] Wong A M K, Lan C. Tai Chi and balance control. Med Sport Sci, 2008; 52: 115-123. doi: 10.1159/000134291 [50] Harper L D, Field A, Corr L D, et al. Tai Chi is safe and effective for the hip joint: A biomechanical perspective. J Aging Phys Act, 2019: 1-11. [51] Yang Y, Li J H, Xu N J, et al. Meta-Analysis of Elderly Lower Body Strength: Different Effects of Tai Chi Exercise on the Knee Joint-Related Muscle Groups. Evid Based Complement Alternat Med, 2021; 2021: 8628182. [52] Zhu Y Q, Peng N, Zhou M, et al. Tai Chi and whole-body vibrating therapy in sarcopenic men in advanced old age: a clinical randomized controlled trial. Eur J Ageing, 2019; 16(3): 273-282. doi: 10.1007/s10433-019-00498-x [53] Li J X, Xu D Q, Hong Y. Changes in muscle strength, endurance, and reaction of the lower extremities with Tai Chi intervention. J Biomech, 2009; 42(8): 967-971. doi: 10.1016/j.jbiomech.2009.03.001 [54] Wayne P M, Gow B J, Hou F, et al. Tai Chi training's effect on lower extremity muscle co-contraction during single- and dual-task gait: Cross-sectional and randomized trial studies. PLoS One, 2021; 16(1): e0242963. doi: 10.1371/journal.pone.0242963 [55] Song Q H, Zhang Q H, Xu R M, et al. Effect of Tai-chi exercise on lower limb muscle strength, bone mineral density and balance function of elderly women. Int J Clin Exp Med, 2014; 7(6): 1569-1576. [56] Taylor-Piliae R E, Newell K A, Cherin R, et al. Effects of Tai Chi and Western exercise on physical and cognitive functioning in healthy community-dwelling older adults. J Aging Phys Act, 2010; 18(3): 261-279. doi: 10.1123/japa.18.3.261 [57] Guo L Y, Yang C P, You Y L, et al. Underlying mechanisms of TaiChi-Chuan training for improving balance ability in the elders. Chin J Integr Med, 2014; 20(6): 409-415. doi: 10.1007/s11655-013-1533-4 [58] Lo J H, U K P, Yiu T, et al. Sarcopenia: Current treatments and new regenerative therapeutic approaches. J Orthop Translat, 2020; 23: 38-52. doi: 10.1016/j.jot.2020.04.002 [59] Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019; 48(1): 16-31. doi: 10.1093/ageing/afy169 [60] Kang Y J, Yoo J I, Baek K W. Differential gene expression profile by RNA sequencing study of elderly osteoporotic hip fracture patients with sarcopenia. J Orthop Translat, 2021; 29: 10-18. doi: 10.1016/j.jot.2021.04.009 [61] Blain H, Jaussent A, Thomas E, et al. Appendicular skeletal muscle mass is the strongest independent factor associated with femoral neck bone mineral density in adult and older men. Exp Gerontol, 2010; 45(9): 679-684. doi: 10.1016/j.exger.2010.04.006 [62] Verschueren S, Gielen E, O'Neill T W, et al. Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men. Osteoporos Int, 2013; 24(1): 87-98. doi: 10.1007/s00198-012-2057-z [63] Chen H, Ma J, Liu A, et al. The association between sarcopenia and fracture in middle-aged and elderly people: A systematic review and meta-analysis of cohort studies. Injury, 2020; 51(4): 804-811. doi: 10.1016/j.injury.2020.02.072 [64] Nielsen B R, Abdulla J, Andersen H E, et al. Sarcopenia and osteoporosis in older people: a systematic review and meta-analysis. Eur Geriatr Med, 2018; 9(4): 419-434. doi: 10.1007/s41999-018-0079-6 [65] Yu R, Leung J, Woo J. Sarcopenia combined with FRAX probabilities improves fracture risk prediction in older Chinese men. J Am Med Dir Assoc, 2014; 15(12): 918-923. doi: 10.1016/j.jamda.2014.07.011 [66] Shaikh A B, Fang H, Li M, et al. Reduced expression of carbonic anhydrase Ⅲ in skeletal muscles could be linked to muscle fatigue: A rat muscle fatigue model. J Orthop Translat, 2020; 22: 116-123. doi: 10.1016/j.jot.2019.08.008 [67] Bucci L R. Selected herbals and human exercise performance. Am J Clin Nutr, 2000; 72(2 Suppl): 624s-636s. [68] Jung S J, Oh M R, Lee D Y, et al. Effect of Ginseng extracts on the improvement of osteopathic and arthritis symptoms in women with osteopenia: A randomized, double-blind, placebo-controlled clinical trial. Nutrients, 2021; 13(10): 3352. doi: 10.3390/nu13103352 [69] Ginseng. In: Drugs and Lactation Database (LactMed)[Internet]. Bethesda (MD): National Library of Medicine (US); 2006. [70] Sellami M, Slimeni O, Pokrywka A, et al. Herbal medicine for sports: a review. J Int Soc Sports Nutr, 2018; 15: 14. doi: 10.1186/s12970-018-0218-y [71] Ma G D, Chiu C H, Hsu Y J, et al. Changbai Mountain Ginseng (Panax ginseng C.A. Mey) extract supplementation improves exercise performance and energy utilization and decreases fatigue-associated parameters in mice. Molecules, 2017; 22(2): 237. doi: 10.3390/molecules22020237 [72] Seok Y M, Yoo J M, Nam Y, et al. Mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING finger protein-1 and atrogin1 through forkhead box O3 in L6 myotubes. J Ethnopharmacol, 2021; 270: 113557. doi: 10.1016/j.jep.2020.113557 [73] Cristina-Souza G, Santos-Mariano A C, Lima-Silva A E, et al. Panax ginseng supplementation increases muscle recruitment, attenuates perceived effort, and accelerates muscle force recovery after an eccentric-based exercise in athletes. J Strength Cond Res, 2022; 36(4): 991-997. doi: 10.1519/JSC.0000000000003555 [74] Shin E J, Jo S, Choi S, et al. Red Ginseng improves exercise endurance by promoting mitochondrial biogenesis and myoblast differentiation. Molecules, 2020; 25(4): 865. doi: 10.3390/molecules25040865 [75] Park J K, Shim J Y, Cho A R, et al. Korean Red Ginseng protects against mitochondrial damage and intracellular inflammation in an animal model of type 2 diabetes mellitus. J Med Food, 2018; 21(6): 544-550. doi: 10.1089/jmf.2017.4059 [76] Cheon J M, Kim D I, Kim K S. Insulin sensitivity improvement of fermented Korean Red Ginseng (Panax ginseng) mediated by insulin resistance hallmarks in old-aged ob/ob mice. J Ginseng Res, 2015; 39(4): 331-337. doi: 10.1016/j.jgr.2015.03.005 [77] Lee S H, Lee H J, Lee Y H, et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother Res, 2012; 26(1): 142-147. doi: 10.1002/ptr.3610 [78] Jung H L, Kwak H E, Kim S S, et al. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Chin Med, 2011; 39(3): 441-450. doi: 10.1142/S0192415X11008944 [79] Estaki M, Noble E G. Noble, North American ginseng protects against muscle damage and reduces neutrophil infiltration after an acute bout of downhill running in rats. Appl Physiol Nutr Metab, 2015; 40(2): 116-121. doi: 10.1139/apnm-2014-0331 [80] Lin C H, Lin Y A, Chen S L, et al. American Ginseng attenuates eccentric exercise-induced muscle damage via the modulation of lipid peroxidation and inflammatory adaptation in males. Nutrients, 2021; 14(1): 78. doi: 10.3390/nu14010078 [81] Hou C W, Lee S D, Kao C L, et al. Improved inflammatory balance of human skeletal muscle during exercise after supplementations of the ginseng-based steroid Rg1. PLoS One, 2015; 10(1): e0116387. [82] Wu J, Saovieng S, Cheng I S, et al. Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle. J Ginseng Res, 2019; 43(4): 580-588. doi: 10.1016/j.jgr.2018.06.002 [83] Feleke M, Bennett S, Chen J, et al. New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration. J Orthop Translat, 2021; 27: 57-66. doi: 10.1016/j.jot.2020.10.012 [84] Widyowati R, Suciati S, Haryadi D M, et al. The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice. J Basic Clin Physiol Pharmacol, 2021; 32(6): 1145-1150. doi: 10.1515/jbcpp-2020-0140 [85] Chen F B, Yin J Y, Liu J Y, et al. Preparation and Determination of Insulin-like Growth Factor I in Deer Antler, Heart and Blood. Zhong Yao Cai, 2014; 37(12): 2155-2158. [86] Jo K, Jang W Y, Yun B S, et al. Effect of Deer Antler extract on muscle differentiation and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced muscle atrophy in C2C12 cells. Food Sci Anim Resour, 2021; 41(4): 623-635. doi: 10.5851/kosfa.2021.e20 [87] Chen J C, Hsiang C Y, Lin Y C, et al. Deer Antler extract improves fatigue effect through altering the expression of genes related to muscle strength in skeletal muscle of mice. Evid Based Complement Alternat Med, 2014; 2014: 540580. [88] Jang S, Park E D, Suh H J, et al. Enhancement of exercise endurance capacity by fermented deer antler in BALB/c mice. Biosci Biotechnol Biochem, 2014; 78(10): 1716-1722. doi: 10.1080/09168451.2014.930324 [89] Huang C C, Chen Y M, Kan N W, et al. Cornucervipantotrichum supplementation improves exercise performance and protects against physical fatigue in mice. Molecules, 2014; 19(4): 4669-4680. doi: 10.3390/molecules19044669 [90] Wang L, Li Y, Guo Y, et al. Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis. CurrPharm Des, 2016; 22(3): 328-349. [91] Deng W M, Zhang P, Huang H, et al. Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures. J Bone Miner Metab, 2012; 30(5): 517-524. doi: 10.1007/s00774-012-0351-7 [92] Ma H, He X, Yang Y, et al. The genus Epimedium: an ethnopharmacological and phytochemical review. J Ethnopharmacol, 2011; 134(3): 519-541. doi: 10.1016/j.jep.2011.01.001 [93] Yong E L, Cheong W F, Huang Z, et al. Randomized, doubleblind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline phosphatase and the osteoclast adaptor protein TRAF6 in postmenopausal women. Phytomedicine, 2021; 91: 153680. doi: 10.1016/j.phymed.2021.153680 [94] Wu H, Lien E J, Lien L L. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res, 2003; 60: 1-57. [95] Li C, Li Q, Mei Q, et al. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sci, 2015; 126: 57-68. doi: 10.1016/j.lfs.2015.01.006 [96] Zhang J, Zhang C, Liu A, et al. Synthesis of Icariin-Zinc and its protective effect on exercise fatigue and reproductive system related glands in male rats. Front Pharmacol, 2021; 12: 611722. doi: 10.3389/fphar.2021.611722 [97] Wang J, Zhu G, Wang X, et al. An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury. J Pharm Pharmacol, 2020; 72(9): 1152-1164. doi: 10.1111/jphp.13314 [98] Chen S Q, Ding L N, Zeng N X, et al. Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway. Biomed Pharmacother, 2019; 115: 108930. doi: 10.1016/j.biopha.2019.108930 [99] Han Y, Jung H W, Park Y K. Effects of Icariin on insulin resistance via the activation of AMPK pathway in C2C12 mouse muscle cells. Eur J Pharmacol, 2015; 758: 60-63. doi: 10.1016/j.ejphar.2015.03.059 [100] Lin Y A, Li Y R, Chang Y C, et al. Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy. Sci Rep, 2021; 11(1): 10790. doi: 10.1038/s41598-021-89039-0 [101] Qin L, Zhang G, Hung W Y, et al. Phytoestrogen-rich herb formula "XLGB" prevents OVX-induced deterioration of musculoskeletal tissues at the hip in old rats. J Bone Miner Metab, 2005; 23 Suppl: 55-61. [102] Kim K Y, Ku S K, Lee K W, et al. Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise. J Ethnopharmacol, 2018; 212: 175-187. doi: 10.1016/j.jep.2017.10.022 [103] Kim J S, Takanche J S, Kim J E, et al. Schisandra chinensis extract ameliorates age-related muscle wasting and bone loss in ovariectomized rats. Phytother Res, 2019; 33(7): 1865-1877. doi: 10.1002/ptr.6375 [104] Park J, Han S, Park H. Effect of Schisandra chinensis extract supplementation on quadriceps muscle strength and fatigue in adult women: A randomized, double-blind, placebo-controlled trial. Int J Environ Res Public Health, 2020; 17(7): 2475. doi: 10.3390/ijerph17072475 [105] Cho S, Hong R, Yim P, et al. An herbal formula consisting of Schisandra chinensis (Turcz. ) Baill, Lyciumchinense Mill and Eucommia ulmoidesOliv alleviates disuse muscle atrophy in rats. J Ethnopharmacol, 2018; 213: 328-339. doi: 10.1016/j.jep.2017.10.008 [106] Yeon M, Choi H, Jun H S. Preventive effects of Schisandrin A, a bioactive component of Schisandra chinensis, on Dexamethasoneinduced muscle atrophy. Nutrients, 2020; 12(5): 1255. doi: 10.3390/nu12051255 [107] Kim J S, Yi H K. Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms. Naunyn Schmiedebergs Arch Pharmacol, 2018; 391(2): 197-206. doi: 10.1007/s00210-017-1449-1 [108] Kim S H, Park K S, Chang M J, et al. Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness, 2005; 45(2): 178-182. -
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