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Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation

Jan Mohammad Omar Yihui Liu

Jan Mohammad Omar, Yihui Liu. Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation[J]. Frigid Zone Medicine, 2025, 5(2): 126-127. doi: 10.1515/fzm-2025-0015
Citation: Jan Mohammad Omar, Yihui Liu. Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation[J]. Frigid Zone Medicine, 2025, 5(2): 126-127. doi: 10.1515/fzm-2025-0015

Hepatic lysosomal lipid remodeling in cold adaptation: Insights into TFEB-PLA2G15-BMP axis regulation

doi: 10.1515/fzm-2025-0015
Funds: Not applicable
More Information
  • [1] Davidson J W, Jain R, T Kizzar T, et al. Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero) phosphate lipids by phospholipase A2 group XV. Cell Metab, 2025; 37(6): 1413-1425 e6. doi: 10.1016/j.cmet.2025.04.015
    [2] Showalter M R, Berg A L, Nagourney A, et al. The emerging and diverse roles of bis(monoacylglycero) phosphate lipids in cellular physiology and disease. Int J Mol Sci, 2020; 21(21): 8067. doi: 10.3390/ijms21218067
    [3] Grabner G F, Fawzy N, Schreiber R, et al. Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice. J Lipid Res, 2020; 61(7): 995-1003. doi: 10.1194/jlr.RA119000516
    [4] Settembre C, de Cegli R, G Mansueto, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol, 2013; 15(6): 647-658. doi: 10.1038/ncb2718
    [5] Nyame K, Xiong J, Alsohybe H N, et al. PLA2G15 is a lysosomal BMP hydrolase and its targeting ameliorates lysosomal disease. Nature, 2025; 642(8067): 474-483. doi: 10.1038/s41586-025-08942-y
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    [9] Karpe F, Pinnick K E. Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes. Nat Rev Endocrinol, 2015; 11(2): 90-100. doi: 10.1038/nrendo.2014.185
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    [13] Alvarez-Valadez K, Sauvat A, Diharce J, et al. Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death. Autophagy, 2025; 21(5): 934-956. doi: 10.1080/15548627.2024.2440842
    [14] Anderson D MG, Ablonczy Z, Koutalos Y, et al. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Sci Rep, 2017; 7(1): 17352. doi: 10.1038/s41598-017-17402-1
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出版历程
  • 收稿日期:  2025-07-04
  • 录用日期:  2025-07-11
  • 网络出版日期:  2025-08-27

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